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dc.contributor.authorArja, Katriann
dc.contributor.authorElgland, Mathias
dc.contributor.authorAppelquist, Hanna
dc.contributor.authorKonradsson, Peter
dc.contributor.authorLindgren, Mikael
dc.contributor.authorNilsson, K. Peter R.
dc.date.accessioned2019-03-12T13:50:34Z
dc.date.available2019-03-12T13:50:34Z
dc.date.created2018-07-04T15:08:12Z
dc.date.issued2018
dc.identifier.citationChemistryOpen. 2018, 7 (7), 495-503.nb_NO
dc.identifier.issn2191-1363
dc.identifier.urihttp://hdl.handle.net/11250/2589738
dc.description.abstractSmall molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2‐fluoro‐2‐deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro‐glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.nb_NO
dc.language.isoengnb_NO
dc.publisherWiley Open Accessnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleSynthesis and characterization of novel fluoro-glycosylated porphyrins that can be utilized as theranostic agentsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber495-503nb_NO
dc.source.volume7nb_NO
dc.source.journalChemistryOpennb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1002/open.201800020
dc.identifier.cristin1595690
dc.description.localcode© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.nb_NO
cristin.unitcode194,66,20,0
cristin.unitnameInstitutt for fysikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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