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dc.contributor.authorKnoester, Marjolein
dc.contributor.authorHelfferich, J
dc.contributor.authorPoelman, Randy
dc.contributor.authorVan Leer-Buter, Coretta
dc.contributor.authorBrouwer, OF
dc.contributor.authorNiesters, Hubert G.M.
dc.contributor.authorAberle, SW
dc.contributor.authorPopow-Kraupp, T
dc.contributor.authorNikolaeva-Glomb, L
dc.contributor.authorRainetova, P
dc.contributor.authorMidgley, Sofie
dc.contributor.authorFischer, T.K.
dc.contributor.authorSimonlatser, G
dc.contributor.authorSavolainen-Kopra, Carita
dc.contributor.authorLina, Bruno
dc.contributor.authorShuffenecker, I
dc.contributor.authorKossorotoff, M
dc.contributor.authorAntona, D
dc.contributor.authorEis-Hübinger, Anna M.
dc.contributor.authorBuderus, S
dc.contributor.authorPanning, Marcus
dc.contributor.authorNowotny, Marlene
dc.contributor.authorKiechle, L
dc.contributor.authorBöttcher, S
dc.contributor.authorTakács, Monika
dc.contributor.authorFarkas, Árpád
dc.contributor.authorLove, A
dc.contributor.authorBaldanti, Fausto
dc.contributor.authorPiralla, Antonio
dc.contributor.authorCapobianchi, Maria R
dc.contributor.authorValli, Mats
dc.contributor.authorEsposito, S
dc.contributor.authorPariani, E
dc.contributor.authorBinda, S
dc.contributor.authorNeuteboom, R
dc.contributor.authorPas, Suzan D.
dc.contributor.authorBenschop, Kimberley
dc.contributor.authorMeijer, A
dc.contributor.authorNordbø, SA
dc.contributor.authorHafström, Maria
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorPfeiffer, H
dc.contributor.authorGuiomar, R
dc.contributor.authorPalminha, P
dc.contributor.authorCosta, I
dc.contributor.authorDias, Assembayev
dc.contributor.authorTecu, C
dc.contributor.authorCherciu, CM
dc.contributor.authorLazarevic, Ivana
dc.contributor.authorFilipovic-Vignjevic, S
dc.contributor.authorBerginc, Natasa
dc.contributor.authorMarguello, MG
dc.contributor.authorCabrerizo, Maria
dc.contributor.authorGarcia-Iniguez, JP
dc.contributor.authorPerez-Castro, S
dc.contributor.authorRodrigo, CP
dc.contributor.authorAntón, Annie
dc.contributor.authorRabella, N
dc.contributor.authorDyrdak, Robert
dc.contributor.authorAlbert, J
dc.contributor.authorKramer, R.B.G.
dc.contributor.authorStacpoole, S
dc.contributor.authorThomas, R
dc.contributor.authorO'Flaherty, N
dc.contributor.authorDrew, RA
dc.contributor.authorTempleton, K
dc.contributor.authorMcDougall, Craig
dc.contributor.authorEunson, Paul
dc.contributor.authorChinchankar, N
dc.contributor.authorShetty, J
dc.contributor.authorMoore, Catherine
dc.contributor.authorWilliams, C
dc.identifier.citationThe Pediatric Infectious Disease Journal. 2019, 38 (1), 16-21.nb_NO
dc.description.abstractBackground: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates in the respiratory tract and causes respiratory disease. Since 2014, EV-D68 has been associated with the neurologic syndrome of acute flaccid myelitis (AFM). Methods: In October 2016, questionnaires were sent out to a European network including 66 virologists and clinicians, to develop an inventory of EV-D68–associated AFM cases in Europe. Clinical and virologic information of case patients was requested. In addition, epidemiologic information on EV testing was collected for the period between March and October 2016. Results: Twenty-nine cases of EV-D68–associated AFM were identified, from 12 different European countries. Five originated from France, 5 from Scotland and 3 each from Sweden, Norway and Spain. Twenty-six were children (median age 3.8 years), 3 were adults. EV-D68 was detected in respiratory materials (n = 27), feces (n = 8) and/or cerebrospinal fluid (n = 2). Common clinical features were asymmetric flaccid limb weakness, cranial nerve deficits and bulbar symptoms. On magnetic resonance imaging, typical findings were hyperintensity of the central cord and/or brainstem; low motor amplitudes with normal conduction velocities were seen on electromyography. Full clinical recovery was rare (n = 3), and 2 patients died. The epidemiologic data from 16 European laboratories showed that of all EV-D68–positive samples, 99% was detected in a respiratory specimen. Conclusions: For 2016, 29 EV-D68–related AFM cases were identified in mostly Western Europe. This is likely an underestimation, because case identification is dependent on awareness among clinicians, adequate viral diagnostics on respiratory samples and the capability of laboratories to type EVs.nb_NO
dc.publisherLippincott, Williams & Wilkinsnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleTwenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016: A Case Series and Epidemiologic Overview.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalThe Pediatric Infectious Disease Journalnb_NO
dc.description.localcode© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND)nb_NO
cristin.unitnameInstitutt for klinisk og molekylær medisin

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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