Vis enkel innførsel

dc.contributor.authorde Jong, Simone
dc.contributor.authorDiniz, Mateus Jose Abdalla
dc.contributor.authorSaloma, Andiara
dc.contributor.authorGadelha, Ary
dc.contributor.authorSantoro, Marcos L.
dc.contributor.authorOta, Vanessa K.
dc.contributor.authorNoto, Cristiano
dc.contributor.authorMorken, Gunnar
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorMelle, Ingrid
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorCurtis, Charles
dc.contributor.authorNewhouse, Stephen J.
dc.contributor.authorPatel, Hamel
dc.contributor.authorHall, Lynsey S.
dc.contributor.authorO`Reilly, Paul F.
dc.contributor.authorBelangero, Sintia I.
dc.contributor.authorBressan, Rodrigo A.
dc.contributor.authorBreen, Gerome
dc.description.abstractPsychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.nb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleApplying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disordernb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalCommunications Biologynb_NO
dc.description.localcode© 2018 The Authors. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.nb_NO
cristin.unitnameInstitutt for psykisk helse

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal