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dc.contributor.authorGarnvik, Lars Elnan
dc.contributor.authorMalmo, Vegard
dc.contributor.authorJanszky, Imre
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorLoennechen, Jan Pål
dc.contributor.authorNes, Bjarne
dc.date.accessioned2019-02-20T10:07:33Z
dc.date.available2019-02-20T10:07:33Z
dc.date.created2018-06-26T14:27:48Z
dc.date.issued2018
dc.identifier.citationEuropean Journal of Preventive Cardiology. 2018, 25 (15), 1646-1652.nb_NO
dc.identifier.issn2047-4873
dc.identifier.urihttp://hdl.handle.net/11250/2586475
dc.description.abstractBackground Atrial fibrillation is the most common heart rhythm disorder, and high body mass index is a well-established risk factor for atrial fibrillation. The objective of this study was to examine the associations of physical activity and body mass index and risk of atrial fibrillation, and the modifying role of physical activity on the association between body mass index and atrial fibrillation. Design The design was a prospective cohort study. Methods This study followed 43,602 men and women from the HUNT3 study in 2006–2008 until first atrial fibrillation diagnosis or end of follow-up in 2015. Atrial fibrillation diagnoses were collected from hospital registers and validated by medical doctors. Cox proportional hazard regression analysis was performed to assess the association between physical activity, body mass index and atrial fibrillation. Results During a mean follow-up of 8.1 years (352,770 person-years), 1459 cases of atrial fibrillation were detected (4.1 events per 1000 person-years). Increasing levels of physical activity were associated with gradually lower risk of atrial fibrillation (p trend 0.069). Overweight and obesity were associated with an 18% (hazard ratio 1.18, 95% confidence interval 1.03–1.35) and 59% (hazard ratio 1.59, 95% confidence interval 1.37–1.84) increased risk of atrial fibrillation, respectively. High levels of physical activity attenuated some of the higher atrial fibrillation risk in obese individuals (hazard ratio 1.53, 95% confidence interval 1.03–2.28 in active and 1.96, 95% confidence interval 1.44–2.67 in inactive) compared to normal weight active individuals. Conclusion Overweight and obesity were associated with increased risk of atrial fibrillation. Physical activity offsets some, but not all, atrial fibrillation risk associated with obesity.nb_NO
dc.language.isoengnb_NO
dc.publisherSAGE Publicationsnb_NO
dc.titlePhysical activity modifies the risk of atrial fibrillation in obese individuals: The HUNT3 studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1646-1652nb_NO
dc.source.volume25nb_NO
dc.source.journalEuropean Journal of Preventive Cardiologynb_NO
dc.source.issue15nb_NO
dc.identifier.doi10.1177/2047487318784365
dc.identifier.cristin1594024
dc.description.localcode© 2018. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: https://doi.org/10.1177/2047487318784365nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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