dc.contributor.author | Groven, Nina | |
dc.contributor.author | Fors, Egil Andreas | |
dc.contributor.author | Iversen, Valentina Cabral | |
dc.contributor.author | White, Linda Rosemary | |
dc.contributor.author | Reitan, Solveig Merete Klæbo | |
dc.date.accessioned | 2019-02-18T14:44:08Z | |
dc.date.available | 2019-02-18T14:44:08Z | |
dc.date.created | 2018-08-03T15:29:01Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Nordic Journal of Psychiatry. 2018, 1-6. | nb_NO |
dc.identifier.issn | 0803-9488 | |
dc.identifier.uri | http://hdl.handle.net/11250/2586046 | |
dc.description.abstract | Purpose: The reports regarding the status of the immune system in patients with chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) have been inconclusive. We approached this question by comparing a strictly defined group of CFS/ME outpatients to healthy control individuals, and thereafter studied cytokines in subgroups with various psychiatric symptoms.
Materials and methods: Twenty patients diagnosed with CFS/ME according to the Fukuda criteria and 20 age- and sex-matched healthy controls were enrolled in the study. Plasma was analysed by ELISA for levels of the cytokines TNF-α, IL-4, IL-6 and IL-10. Participants also answered questionnaires regarding health in general, and psychiatric symptoms in detail.
Results: Increased plasma levels of TNF-α in CFS/ME patients almost reached significance compared to healthy controls (p = .056). When studying the CFS/ME and control groups separately, there was a significant correlation between TNF-α and The Hospital Anxiety and Depression Scale (HADS) depressive symptoms in controls only, not in the CFS/ME group. A correlation between IL-10 and psychoticism was found in both groups, whereas the correlation for somatisation was seen only in the CFS/ME group. When looking at the total population, there was a significant correlation between TNF-α and both the HADS depressive symptoms and the SCL-90-R cluster somatisation. Also, there was a significant association between IL-10 and the SCL-90-R cluster somatisation when analyzing the cohort (patients and controls together).
Conclusions: These findings indicate that immune activity in CFS/ME patients deviates from that of healthy controls, which implies potential pathogenic mechanisms and possible therapeutic approaches to CFS/ME. More comprehensive studies should be carried out on defined CFS/ME subgroups. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Taylor & Francis | nb_NO |
dc.relation.uri | https://www.tandfonline.com/doi/full/10.1080/08039488.2018.1493747 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.subject | Nevropsykiatri | nb_NO |
dc.subject | Neuropsychiatry | nb_NO |
dc.title | Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls | nb_NO |
dc.title.alternative | Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.subject.nsi | VDP::Basale medisinske, odontologiske og veterinærmedisinske fag: 710 | nb_NO |
dc.subject.nsi | VDP::Basic medical, dental and veterinary sciences: 710 | nb_NO |
dc.source.pagenumber | 1-6 | nb_NO |
dc.source.volume | 72 | nb_NO |
dc.source.journal | Nordic Journal of Psychiatry | nb_NO |
dc.source.issue | 8 | nb_NO |
dc.identifier.doi | 10.1080/08039488.2018.1493747 | |
dc.identifier.cristin | 1599690 | |
dc.description.localcode | (C) 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | nb_NO |
cristin.unitcode | 194,65,35,0 | |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,30,0 | |
cristin.unitname | Institutt for psykisk helse | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |