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dc.contributor.authorLøhre, Erik Torbjørn
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorBrunelli, Cinzia
dc.contributor.authorKnudsen, Anne Kari
dc.contributor.authorKaasa, Stein
dc.contributor.authorKlepstad, Pål
dc.date.accessioned2019-02-15T10:31:11Z
dc.date.available2019-02-15T10:31:11Z
dc.date.created2018-11-22T13:27:12Z
dc.date.issued2018
dc.identifier.issn2193-8237
dc.identifier.urihttp://hdl.handle.net/11250/2585685
dc.description.abstractIntroduction Different definitions of breakthrough pain (BTP) influence the observed BTP prevalence. This study examined BTP prevalence variability due to use of different cutoffs for controlled background pain, different assessment periods for background pain, and difference between worst and average pain intensity (PI). Methods Cancer patients from the EPCRC-CSA study who reported flare-ups of pain past 24 h were potential BTP cases. BTP prevalence was calculated for different cutoffs for background PI on numeric rating scales (NRS 0–10) for the past week, past 48 and past 24 h period. Furthermore, BTP cases were categorized based on the difference between maximum and average PI past 24 h (range, 0 to > 2 points, NRS 0–10). Results Of 696 respondents, 302 patients (43.4%) reported pain flares the past 24 h. The BTP prevalence when using a defined background PI ≤ 4 for the past week was 19.8%. This number varied for different defined cutoffs for background PI. Actual background PI and BTP prevalence also varied between the assessment periods “past week”, “past 48 h”, and “past 24 h” (PI 4.0, 3.6, and 3.4; BTP prevalence 19.8, 22.7, and 24.9% for background PI ≤ 4). For patients with background PI ≤ 4 past week, 105 had a difference between maximum and average PI ≥ one point and 48 had a difference > two points. Conclusions The reported BTP prevalence is dependent on the cutoff for background PI in the BTP definition, population background PI during the assessment period, and defined cutoff for the difference between worst and average PI.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Verlagnb_NO
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no
dc.titlePain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Studynb_NO
dc.title.alternativePain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.journalPain and Therapynb_NO
dc.identifier.doi10.1007/s40122-018-0107-8
dc.identifier.cristin1633771
dc.description.localcode© The Author(s) 2018. Open access, BY-NCnb_NO
cristin.unitcode194,65,15,0
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International