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dc.contributor.authorAgnihotri, Naveen
dc.contributor.authorHawkins, Robert
dc.contributor.authorKandel, ER
dc.contributor.authorKentros, Clifford
dc.date.accessioned2019-01-21T14:48:18Z
dc.date.available2019-01-21T14:48:18Z
dc.date.created2018-11-21T12:30:45Z
dc.date.issued2004
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11250/2581624
dc.description.abstractThe hippocampus is critical for formation of spatial memories. Hippocampal pyramidal neurons in freely behaving animals exhibit spatially selective firing patterns, which taken together form an internal representation of the environment. This representation is thought to contribute to the hippocampal spatial memory system. Behavioral long-term memories differ from short-term memories in requiring the synthesis of new proteins. Does the development of the internal hippocampal representation also require the synthesis of new proteins? We found that blocking protein synthesis in the brain of mice by 95% does not affect short-term stability of newly formed hippocampal place fields but abolishes stability in the long term. By contrast, inhibiting protein synthesis does not affect the retention and recall of previously established fields in a familiar environment, indicating that protein synthesis-dependent reconsolidation is not required for recall. Our results indicate that place fields parallel both behavioral memories and the late phase of long-term potentiation in requiring the synthesis of new proteins for consolidation.nb_NO
dc.language.isoengnb_NO
dc.publisherNational Academy of Sciencesnb_NO
dc.titleThe long-term stability of new hippocampal place fields requires new protein synthesis.nb_NO
dc.title.alternativeThe long-term stability of new hippocampal place fields requires new protein synthesis.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americanb_NO
dc.identifier.doi10.1073/pnas.0400385101
dc.identifier.cristin1633237
dc.description.localcode© 2004 by The National Academy of Sciences of the USAnb_NO
cristin.unitcode194,65,60,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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