dc.contributor.author | Schou, Morten Brix | |
dc.contributor.author | Sæther, Sverre Georg | |
dc.contributor.author | Borowski, K | |
dc.contributor.author | Teegen, B | |
dc.contributor.author | Kondziella, Daniel | |
dc.contributor.author | Stoecker, W | |
dc.contributor.author | Vaaler, Arne Einar | |
dc.contributor.author | Reitan, Solveig Merete Klæbo | |
dc.date.accessioned | 2019-01-21T08:24:32Z | |
dc.date.available | 2019-01-21T08:24:32Z | |
dc.date.created | 2016-09-28T09:38:17Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Psychological Medicine. 2016, 46 (16), 3303-3313. | nb_NO |
dc.identifier.issn | 0033-2917 | |
dc.identifier.uri | http://hdl.handle.net/11250/2581370 | |
dc.description.abstract | Background
Autoimmune encephalitis associated with anti-neuronal antibodies may be challenging to distinguish from primary psychiatric disorders. The significance of anti-neuronal antibodies in psychiatric patients without clear evidence of autoimmune encephalitis is unknown. We investigated the serum prevalence of six anti-neuronal autoantibodies in a cohort of unselected patients admitted to acute psychiatric care.
Method
Serum was drawn from 925 patients admitted to acute psychiatric in-patient care. Psychiatric diagnoses were set according to International Classification of Diseases (ICD)-10 criteria. Antibody analysis was performed with an indirect immunofluorescence test for N-methyl d-aspartate receptor (NMDAR) antibodies and five other anti-neuronal autoantibodies of the immunoglobulin (Ig) classes IgA, IgG and IgM isotype.
Results
Anti-neuronal autoantibodies were found in 11.6% of patients: NMDAR antibodies in 7.6%, contactin-associated protein-like 2 (CASPR2) antibodies in 2.5%, glutamic acid decarboxylase-65 (GAD65) antibodies in 1.9%, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antibodies in 0.1%. Leucine-rich glioma-inactivated protein-1 (LGI1) and γ-aminobutyric acid B (GABAB) receptor antibodies were not detected. NMDAR antibodies of class IgG were present in five patients only (0.5%). NMDAR antibodies of all Ig classes were equally prevalent in patients with and without psychosis. There were no significant differences in antibody prevalence in the different diagnostic categories, except for a higher odds ratio of being NMDAR antibody positive for patients without a specific psychiatric diagnosis.
Conclusions
NMDAR IgG autoantibodies, which are known to be strongly associated with anti-NMDAR encephalitis, were rarely found. CASPR2 and GAD65 antibodies were more frequently encountered in the present study than previously reported. Further research on the clinical significance of anti-neuronal autoantibodies in patients with acute psychiatric symptoms is needed. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Cambridge University Press | nb_NO |
dc.title | Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 3303-3313 | nb_NO |
dc.source.volume | 46 | nb_NO |
dc.source.journal | Psychological Medicine | nb_NO |
dc.source.issue | 16 | nb_NO |
dc.identifier.doi | 10.1017/S0033291716002038 | |
dc.identifier.cristin | 1386713 | |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2016 by Cambridge University Press | nb_NO |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 194,65,35,0 | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | Institutt for psykisk helse | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |