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dc.contributor.authorMoser, Edvard Ingjald
dc.contributor.authorTsao, Albert
dc.contributor.authorSugar, Jørgen
dc.contributor.authorWang, Cheng-Cheng
dc.contributor.authorMoser, May-Britt
dc.contributor.authorKnierim, James
dc.date.accessioned2018-12-20T08:05:20Z
dc.date.available2018-12-20T08:05:20Z
dc.date.created2018-11-06T15:21:09Z
dc.date.issued2018
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/11250/2578403
dc.description.abstractThe encoding of time and its binding to events are crucial for episodic memory, but how these processes are carried out in hippocampal–entorhinal circuits is unclear. Here we show in freely foraging rats that temporal information is robustly encoded across time scales from seconds to hours within the overall population state of the lateral entorhinal cortex. Similarly pronounced encoding of time was not present in the medial entorhinal cortex or in hippocampal areas CA3–CA1. When animals’ experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved. The findings suggest that populations of lateral entorhinal cortex neurons represent time inherently through the encoding of experience. This representation of episodic time may be integrated with spatial inputs from the medial entorhinal cortex in the hippocampus, allowing the hippocampus to store a unified representation of what, where and when.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Researchnb_NO
dc.titleIntegrating time from experience in the lateral entorhinal cortexnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber57–62nb_NO
dc.source.volume561nb_NO
dc.source.journalNaturenb_NO
dc.identifier.doi10.1038/s41586-018-0459-6
dc.identifier.cristin1627647
dc.description.localcode© 2018. This is the authors’ accepted and refereed manuscript to the article. Locked until 29.2.2019 due to copyright restrictions.nb_NO
cristin.unitcode194,65,60,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2A


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