dc.contributor.author | Raju, Rajesh | |
dc.contributor.author | Bandyopadhyay, Sulalit | |
dc.contributor.author | Sharma, Anuvansh | |
dc.contributor.author | Gonzalez, Susana Villa | |
dc.contributor.author | Carlsen, Per Henning | |
dc.contributor.author | Gautun, Odd Reidar | |
dc.contributor.author | Glomm, Wilhelm | |
dc.date.accessioned | 2018-07-13T09:00:59Z | |
dc.date.available | 2018-07-13T09:00:59Z | |
dc.date.created | 2018-03-19T08:46:45Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/11250/2505334 | |
dc.description.abstract | We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The core-shell nanogels were synthesized using an optimized two-stage seeded polymerization methodology. The core-shell nanogels show a narrow size distribution and controllable physico-chemical properties. The hydrodynamic sizes, charge distributions, temperature-induced volume phase transition behaviors, pH-responsive behaviors and drug loading capabilities of the core-shell nanogels were investigated using transmission electron microscopy, zeta potential measurements, dynamic light scattering and UV-Vis spectroscopy. The size of the core-shell nanogels was controlled by polymerizing NIPAm with crosslinker poly(ethylene glycol) dimethacrylate (PEGDMA) of different molecular weights (Mn-200, 400, 550 and 750 g/mol) during the core synthesis. It was found that the swelling/deswelling kinetics of the nanogels was sharp and reversible; with its volume phase transition temperature in the range of 40–42 °C. Furthermore, the nanogels loaded with l-3,4-dihydroxyphenylalanine (L-DOPA), using a modified breathing-in mechanism, showed high loading and encapsulation efficiencies, providing potential possibilities of such nanogels for biomedical applications. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | MDPI | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | Polymers | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.3390/polym10030309 | |
dc.identifier.cristin | 1573762 | |
dc.description.localcode | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,66,30,0 | |
cristin.unitcode | 194,66,35,0 | |
cristin.unitcode | 194,66,25,0 | |
cristin.unitcode | 194,65,60,0 | |
cristin.unitname | Institutt for kjemisk prosessteknologi | |
cristin.unitname | Institutt for materialteknologi | |
cristin.unitname | Institutt for kjemi | |
cristin.unitname | Kavliinstitutt for nevrovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |