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dc.contributor.authorRaju, Rajesh
dc.contributor.authorBandyopadhyay, Sulalit
dc.contributor.authorSharma, Anuvansh
dc.contributor.authorGonzalez, Susana Villa
dc.contributor.authorCarlsen, Per Henning
dc.contributor.authorGautun, Odd Reidar
dc.contributor.authorGlomm, Wilhelm
dc.date.accessioned2018-07-13T09:00:59Z
dc.date.available2018-07-13T09:00:59Z
dc.date.created2018-03-19T08:46:45Z
dc.date.issued2018
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/11250/2505334
dc.description.abstractWe report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The core-shell nanogels were synthesized using an optimized two-stage seeded polymerization methodology. The core-shell nanogels show a narrow size distribution and controllable physico-chemical properties. The hydrodynamic sizes, charge distributions, temperature-induced volume phase transition behaviors, pH-responsive behaviors and drug loading capabilities of the core-shell nanogels were investigated using transmission electron microscopy, zeta potential measurements, dynamic light scattering and UV-Vis spectroscopy. The size of the core-shell nanogels was controlled by polymerizing NIPAm with crosslinker poly(ethylene glycol) dimethacrylate (PEGDMA) of different molecular weights (Mn-200, 400, 550 and 750 g/mol) during the core synthesis. It was found that the swelling/deswelling kinetics of the nanogels was sharp and reversible; with its volume phase transition temperature in the range of 40–42 °C. Furthermore, the nanogels loaded with l-3,4-dihydroxyphenylalanine (L-DOPA), using a modified breathing-in mechanism, showed high loading and encapsulation efficiencies, providing potential possibilities of such nanogels for biomedical applications.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSynthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributionsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume10nb_NO
dc.source.journalPolymersnb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.3390/polym10030309
dc.identifier.cristin1573762
dc.description.localcode© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,66,30,0
cristin.unitcode194,66,35,0
cristin.unitcode194,66,25,0
cristin.unitcode194,65,60,0
cristin.unitnameInstitutt for kjemisk prosessteknologi
cristin.unitnameInstitutt for materialteknologi
cristin.unitnameInstitutt for kjemi
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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