dc.contributor.author | Bandyopadhyay, Sulalit | |
dc.contributor.author | Andersen, Marte Kee | |
dc.contributor.author | Awais, Muhammad | |
dc.contributor.author | Sharma, Anuvansh | |
dc.contributor.author | Raju, Rajesh | |
dc.contributor.author | McDonagh, Birgitte Hjelmeland | |
dc.contributor.author | Glomm, Wilhelm | |
dc.date.accessioned | 2018-07-12T09:03:14Z | |
dc.date.available | 2018-07-12T09:03:14Z | |
dc.date.created | 2016-11-04T14:38:40Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Colloid and Polymer Science. 2016, 294 (12), 1929-1942. | nb_NO |
dc.identifier.issn | 0303-402X | |
dc.identifier.uri | http://hdl.handle.net/11250/2505212 | |
dc.description.abstract | Here, a synthetic method has been optimized for the synthesis of thermoresponsive and pH-responsive poly(N-isopropylacrylamide-co-acrylic acid) nanogels which are subsequently loaded with cytochrome C by using a modified breathing-in mechanism. Physico-chemical properties mapped by using dynamic light scattering (DLS) and differential scanning calorimetry (DSC) confirm the swelling/deswelling kinetics as reversible with a volume phase transition temperature (VPTT) of ~39 °C. Fe@Au nanoparticles were incorporated inside the nanogel networks by using two different methods: coating and in situ growth. The latter bears closer resemblance to the nanogels only, while the former follows the trend of bare Fe@Au nanoparticles. High loading (~96 %) and encapsulation (500 μg/mg of nanogels) of cytochrome C were obtained. Release experiments performed by using a dialysis set-up and monitored by using UV-vis spectroscopy show the highest release at 40 °C and pH 3.2 (high temperature, low pH), with maximum release from the Fe@Au-coated nanogels that also show a reverse swelling-collapse trend. The location of the drug, the incorporation and presence of Fe@Au nanoparticles and the drug incorporation method are found to control both the drug release mechanism and kinetics. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Verlag | nb_NO |
dc.title | Incorporation of Fe@Au nanoparticles into multiresponsive pNIPAM-AAc colloidal gels modulates drug uptake and release | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 1929-1942 | nb_NO |
dc.source.volume | 294 | nb_NO |
dc.source.journal | Colloid and Polymer Science | nb_NO |
dc.source.issue | 12 | nb_NO |
dc.identifier.doi | 10.1007/s00396-016-3944-1 | |
dc.identifier.cristin | 1397443 | |
dc.relation.project | Norges forskningsråd: 245963 | nb_NO |
dc.description.localcode | This is a post-peer-review, pre-copyedit version of an article published in [Colloid and Polymer Science]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00396-016-3944-1 | nb_NO |
cristin.unitcode | 194,66,30,0 | |
cristin.unitcode | 194,66,25,0 | |
cristin.unitname | Institutt for kjemisk prosessteknologi | |
cristin.unitname | Institutt for kjemi | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |