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dc.contributor.authorWitter, Menno
dc.contributor.authorOhara, Shinya
dc.contributor.authorOnodera, Mariko
dc.contributor.authorSimonsen, Øyvind Wilsgård
dc.contributor.authorYoshino, Rintaro
dc.contributor.authorHioki, Hiroyuki
dc.contributor.authorIijima, Toshio
dc.contributor.authorTsutsui, Ken-Ichiro
dc.date.accessioned2018-07-09T07:25:44Z
dc.date.available2018-07-09T07:25:44Z
dc.date.created2018-07-04T17:24:05Z
dc.date.issued2018
dc.identifier.citationCell reports. 2018, 24 107-116.nb_NO
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/11250/2504729
dc.description.abstractLayer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal projections, whereas the superficial-sublayer LVa, immunonegative for Ctip2, originates the main outputs of EC. This disrupts the proposed role of EC as mediating hippocampal-cortical interactions. With the use of specific (trans)synaptic tracing approaches, we report that, in medial entorhinal cortex, layer Vb neurons innervate neurons in layers Va, II, and III. A similar circuitry exists in the lateral entorhinal cortex. We conclude that EC-layer Vb neurons mediate two circuits in the hippocampus-memory system: (1) a hippocampal output circuit to telencephalic areas by projecting to layer Va and (2) a feedback projection, sending information back to the EC-hippocampal loop via neurons in layers II and III.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleIntrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Ratnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber107-116nb_NO
dc.source.volume24nb_NO
dc.source.journalCell reportsnb_NO
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2018.06.014
dc.identifier.cristin1595717
dc.description.localcode© 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,65,60,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal