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dc.contributor.authorBalasuriya, Chandima Nirupa Dilruks
dc.contributor.authorEvensen, Kari Anne Indredavik
dc.contributor.authorMosti, Mats Peder
dc.contributor.authorBrubakk, Ann-Mari
dc.contributor.authorJacobsen, Geir Wenberg
dc.contributor.authorIndredavik, Marit Sæbø
dc.contributor.authorSchei, Berit
dc.contributor.authorStunes, Astrid Kamilla
dc.contributor.authorSyversen, Unni
dc.date.accessioned2018-06-28T09:11:21Z
dc.date.available2018-06-28T09:11:21Z
dc.date.created2017-06-15T11:14:18Z
dc.date.issued2017
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism. 2017, 102 (7), 2491-2500.nb_NO
dc.identifier.issn0021-972X
dc.identifier.urihttp://hdl.handle.net/11250/2503522
dc.description.abstractContext and Objectives: Peak bone mass (PBM) is regarded as the most important determinant of osteoporosis. Growing evidence suggests a role of intrauterine programming in skeletal development. We examined PBM and trabecular bone score (TBS) in adults born preterm with very low birth weight (VLBW) or small for gestational age (SGA) at term compared with term-born controls. Design, Setting, Participants, and Outcomes: This follow-up cohort study included 186 men and women (25 to 28 years); 52 preterm VLBW (≤1500 g), 59 term-born SGA (<10th percentile), and 75 controls (>10th percentile). Main outcome was bone mineral density (BMD) by dual x-ray absorptiometry. Secondary outcomes were bone mineral content (BMC), TBS, and serum bone markers. Results: VLBW adults had lower BMC and BMD vs controls, also when adjusted for height, weight, and potential confounders, with the following BMD Z-score differences: femoral neck, 0.6 standard deviation (SD) (P = 0.003); total hip, 0.4 SD (P = 0.01); whole body, 0.5 SD (P = 0.007); and lumbar spine, 0.3 SD (P = 0.213). The SGA group displayed lower spine BMC and whole-body BMD Z-scores, but not after adjustment. Adjusted odds ratios for osteopenia/osteoporosis were 2.4 and 2.0 in VLBW and SGA adults, respectively. TBS did not differ between groups, but it was lower in men than in women. Serum Dickkopf-1 was higher in VLBW subjects vs controls; however, it was not significant after adjustment for multiple comparisons. Conclusions: Both low-birth-weight groups displayed lower PBM and higher frequency of osteopenia/osteoporosis, implying increased future fracture risk. The most pronounced bone deficit was seen in VLBW adults.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Press (OUP)nb_NO
dc.titlePeak bone mass and bone microarchitecture in adults born with low birth weight preterm or at term: A cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber2491-2500nb_NO
dc.source.volume102nb_NO
dc.source.journalJournal of Clinical Endocrinology and Metabolismnb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1210/jc.2016-3827
dc.identifier.cristin1476287
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2017 by Oxford University Pressnb_NO
cristin.unitcode194,65,15,0
cristin.unitcode194,65,20,0
cristin.unitcode194,65,35,5
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameRKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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