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dc.contributor.authorWang, Q
dc.contributor.authorChen, Q
dc.contributor.authorZhu, L
dc.contributor.authorChen, M
dc.contributor.authorXu, W
dc.contributor.authorPanday, S
dc.contributor.authorWang, Z
dc.contributor.authorLi, A
dc.contributor.authorRøe, Oluf Dimitri
dc.contributor.authorChen, R
dc.contributor.authorWang, S
dc.contributor.authorZhang, R
dc.contributor.authorZhou, J
dc.date.accessioned2018-06-22T09:32:51Z
dc.date.available2018-06-22T09:32:51Z
dc.date.created2017-09-26T13:27:13Z
dc.date.issued2017
dc.identifier.citationOncogenesis. 2017, 6(7).nb_NO
dc.identifier.issn2157-9024
dc.identifier.urihttp://hdl.handle.net/11250/2502652
dc.description.abstractPlatinum chemotherapeutics are widely used to treat solid malignant tumors, including gastric cancer (GC). Drug resistance to platinum compounds may result in cancer relapse and decreased survival. The identification and development of novel agents to reactivate apoptosis pathways in platinum-resistant cancer cells is therefore necessary. Here we report that cisplatin-resistant human GC cells (BGC823/DDP and SGC7901/DDP) but not their parental cells (BGC823 and SGC7901) exhibit high sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a result of overexpression of death receptor 4 (DR4). Furthermore, we found that JWA, a molecule that promotes cisplatin-induced apoptosis in GC cells, suppressed TRAIL-induced apoptosis via negative regulation of DR4. Mechanistically, JWA promoted the ubiquitination of DR4 at K273 via upregulation of the ubiquitin ligase membrane-associated RING-CH-8 (MARCH8). In human GC tissues, JWA and DR4 protein levels were negatively correlated. Thus TRAIL may serve as an auxiliary treatment for cisplatin-resistant GC, and JWA may be a potential predictive marker of TRAIL sensitivity and may improve personalized therapeutics for treating human GC.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Naturenb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleJWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cellsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume6nb_NO
dc.source.journalOncogenesisnb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1038/oncsis.2017.57
dc.identifier.cristin1498311
dc.description.localcode© The Author(s) 2017. Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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