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dc.contributor.authorHaukaas, Tonje Husby
dc.contributor.authorEuceda, Leslie R.
dc.contributor.authorGiskeødegård, Guro F.
dc.contributor.authorBathen, Tone Frost
dc.date.accessioned2018-06-05T11:53:58Z
dc.date.available2018-06-05T11:53:58Z
dc.date.created2017-05-16T11:03:10Z
dc.date.issued2017
dc.identifier.citationMetabolites. 2017, 7 (2:18), 1-16.nb_NO
dc.identifier.issn2218-1989
dc.identifier.urihttp://hdl.handle.net/11250/2500376
dc.description.abstractDespite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast cancer patients with similar diagnosis might have different prognosis and response to treatment. Thus, deeper understanding of individual tumor properties is necessary. Cancer cells must be able to convert nutrients to biomass while maintaining energy production, which requires reprogramming of central metabolic processes in the cells. This phenomenon is increasingly recognized as a potential target for treatment, but also as a source for biomarkers that can be used for prognosis, risk stratification and therapy monitoring. Magnetic resonance (MR) metabolomics is a widely used approach in translational research, aiming to identify clinically relevant metabolic biomarkers or generate novel understanding of the molecular biology in tumors. Ex vivo proton high-resolution magic angle spinning (HR MAS) MR spectroscopy is widely used to study central metabolic processes in a non-destructive manner. Here we review the current status for HR MAS MR spectroscopy findings in breast cancer in relation to glucose, amino acid and choline metabolism.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPI AGnb_NO
dc.relation.urihttp://www.mdpi.com/2218-1989/7/2/18
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMetabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samplesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-16nb_NO
dc.source.volume7nb_NO
dc.source.journalMetabolitesnb_NO
dc.source.issue2:18nb_NO
dc.identifier.doi10.3390/metabo7020018
dc.identifier.cristin1470441
dc.description.localcode© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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