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dc.contributor.authorJustice, Anne E.
dc.contributor.authorWinkler, Thomas W.
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorGraff, Misa
dc.contributor.authorFisher, Virginia A.
dc.contributor.authorYoung, Kristin
dc.contributor.authorBarata, Llilda
dc.contributor.authorDeng, Xuan
dc.contributor.authorCzajkowski, Jacek
dc.contributor.authorHadley, David
dc.contributor.authorNgwa, Julius S.
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorChu, Audrey Y.
dc.contributor.authorHeard-Costa, Nancy L.
dc.contributor.authorLim, Elise
dc.contributor.authorPerez, Jeremiah
dc.contributor.authorEicher, John D.
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorXue, Luting
dc.contributor.authorMahajan, Anubha
dc.contributor.authorRenström, Frida
dc.contributor.authorWu, Joseph
dc.contributor.authorQi, Qibin
dc.contributor.authorAhmad, Shafqat
dc.contributor.authorAlfred, Tamuno
dc.contributor.authorAmin, Najaf
dc.contributor.authorBielak, Lawrence F.
dc.contributor.authorBonnefond, Amelie
dc.contributor.authorBragg, Jennifer
dc.contributor.authorCadby, Gemma
dc.contributor.authorChittani, Martina
dc.contributor.authorCoggeshall, Scott
dc.contributor.authorCorre, Tanguy
dc.contributor.authorDirek, Nese
dc.contributor.authorEriksson, Joel
dc.contributor.authorFischer, Krista
dc.contributor.authorGorski, Mathias
dc.contributor.authorHarder, Marie Neergaard
dc.contributor.authorHorikoshi, Momoko
dc.contributor.authorHuang, Tao
dc.contributor.authorHuffman, Jennifer E.
dc.contributor.authorJackson, Anne U.
dc.contributor.authorJustesen, Johanne Marie
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorKinnunen, Leena
dc.contributor.authorKleber, Marcus E.
dc.contributor.authorKomulainen, Pirjo
dc.contributor.authorKumari, Meena
dc.contributor.authorLim, Unhee
dc.contributor.authorLuan, Jian'an
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMangino, Massimo
dc.contributor.authorManichaikul, Ani
dc.contributor.authorMarten, Jonathan
dc.contributor.authorMiddelberg, Rita P.S.
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorNavarro, Pau
dc.contributor.authorPérusse, Louis
dc.contributor.authorPervjakova, Natalia
dc.contributor.authorSarti, Cinzia
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorStančáková, Alena
dc.contributor.authorStrawbridge, Rona J.
dc.contributor.authorStringham, Heather M.
dc.contributor.authorSung, Yun Ju
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorTeumer, Alexander
dc.contributor.authorTrompet, Stella
dc.contributor.authorVan Der Laan, Sander W.
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V.
dc.contributor.authorVedantam, Sailaja L.
dc.contributor.authorVerweij, Niek
dc.contributor.authorVink, Jacqueline M.
dc.contributor.authorVitart, Veronique
dc.contributor.authorWu, Ying
dc.contributor.authorYengo, Loic
dc.contributor.authorZhang, Weihua
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorZimmermann, Martina E.
dc.contributor.authorZubair, Niha
dc.contributor.authorAbecasis, Gonçalo R.
dc.contributor.authorAdair, Linda S.
dc.contributor.authorAfaq, Saima
dc.contributor.authorAfzal, Uzma
dc.contributor.authorBakker, Stephan J.L.
dc.contributor.authorBartz, Traci M.
dc.contributor.authorBeilby, John
dc.contributor.authorBergman, Richard N.
dc.contributor.authorBergmann, Sven
dc.contributor.authorBiffar, Reiner
dc.contributor.authorBlangero, John
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBonnycastle, Lori L.
dc.contributor.authorBottinger, Erwin
dc.contributor.authorBraga, Daniele
dc.contributor.authorBuckley, Brendan M.
dc.contributor.authorBuyske, Steve
dc.contributor.authorCampbell, Harry
dc.contributor.authorChambers, John C.
dc.contributor.authorCollins, Francis S.
dc.contributor.authorCurran, Joanne E.
dc.contributor.authorDe Borst, Gert J.
dc.contributor.authorde Craen, Anton J.M.
dc.contributor.authorde Geus, Eco J.C.
dc.contributor.authorDedoussis, George
dc.contributor.authorDelgado, Graciela E.
dc.contributor.authorDen Ruijter, Hester M.
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorEriksson, Anna L.
dc.contributor.authorEsko, Tonu
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFord, Ian
dc.contributor.authorForrester, Terrence
dc.contributor.authorGertow, Karl
dc.contributor.authorGigante, Bruna
dc.contributor.authorGlorioso, Nicola
dc.contributor.authorGong, Jian
dc.contributor.authorGrallert, Harald
dc.contributor.authorGrammer, Tanja B.
dc.contributor.authorGrarup, Niels
dc.contributor.authorHaitjema, Saskia
dc.contributor.authorHallmans, Goran
dc.contributor.authorHamsten, Anders
dc.contributor.authorHansen, Torben
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHassinen, Maija
dc.contributor.authorHastie, Nicholas D.
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorHernandez, Dena
dc.contributor.authorHindorff, Lucia
dc.contributor.authorHocking, Lynne J.
dc.contributor.authorHollensted, Mette
dc.contributor.authorHolmen, Oddgeir Lingaas
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke Jan
dc.contributor.authorHuang, Jie
dc.contributor.authorHung, Joseph
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorIngelsson, Erik
dc.contributor.authorJames, Alan L.
dc.contributor.authorJansson, John-Olov
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorJhun, Min A.
dc.contributor.authorJørgensen, Marit E.
dc.contributor.authorJuonala, Markus
dc.contributor.authorKähönen, Mika
dc.contributor.authorKarlsson, Magnus
dc.contributor.authorKoistinen, Heikki A
dc.contributor.authorKolcic, Ivana
dc.contributor.authorKolovou, Genovefa
dc.contributor.authorKooperberg, Charles
dc.contributor.authorKrämer, Bernhard K.
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorKvaløy, Kirsti
dc.contributor.authorLakka, Timo A.
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorLeander, Karin
dc.contributor.authorLee, Nanette R.
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M.
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLobbens, Stephane
dc.contributor.authorLoh, Marie
dc.contributor.authorLorentzon, Mattias
dc.contributor.authorLuben, Robert
dc.contributor.authorLubke, Gitta
dc.contributor.authorLudolph-Donislawski, Anja
dc.contributor.authorLupoli, Sara
dc.contributor.authorMadden, Pamela A.F.
dc.contributor.authorMännikkö, Reija
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMcKenzie, Colin A.
dc.contributor.authorMcKnight, Barbara
dc.contributor.authorMellström, Dan
dc.contributor.authorMenni, Cristina
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMusk, A. Bill
dc.contributor.authorNarisu, Narisu
dc.contributor.authorNauck, Matthias
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorOldehinkel, Albertine J.
dc.contributor.authorOlden, Matthias
dc.contributor.authorOng, Ken K.
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorPeyser, Patricia A.
dc.contributor.authorPisinger, Charlotta
dc.contributor.authorPorteous, David J.
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorRao, Dabeeru C.
dc.contributor.authorRasmussen-Torvik, Laura J.
dc.contributor.authorRawal, Rajesh
dc.contributor.authorRice, Treva
dc.contributor.authorRidker, Paul M.
dc.contributor.authorRose, Lynda M.
dc.contributor.authorBien, Stephanie A.
dc.contributor.authorRudan, Igor
dc.contributor.authorSanna, Serena
dc.contributor.authorSarzynski, Mark A.
dc.contributor.authorSattar, Naveed
dc.contributor.authorSavonen, Kai
dc.contributor.authorSchlessinger, David
dc.contributor.authorScholtens, Salome
dc.contributor.authorSchurmann, Claudia
dc.contributor.authorScott, Robert A.
dc.contributor.authorSennblad, Bengt
dc.contributor.authorSiemelink, Marten A.
dc.contributor.authorSilbernagel, Günther
dc.contributor.authorSlagboom, P. Eline
dc.contributor.authorSnieder, Harold
dc.contributor.authorStaessen, Jan A.
dc.contributor.authorStott, David J.
dc.contributor.authorSwertz, Morris A.
dc.contributor.authorSwift, Amy J.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorTayo, Bamidele O.
dc.contributor.authorThorand, Barbara
dc.contributor.authorThuillier, Dorothee
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorVandenput, Liesbeth
dc.contributor.authorVohl, Marie-Claude
dc.contributor.authorVölzke, Henry
dc.contributor.authorVonk, Judith M.
dc.contributor.authorWaeber, Gérard
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorWestendorp, Rudi G.J.
dc.contributor.authorWild, Sarah
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWolffenbuttel, Bruce H.R.
dc.contributor.authorWong, Andrew
dc.contributor.authorWright, Alan F.
dc.contributor.authorZhao, Wei
dc.contributor.authorZillikens, M. Carola
dc.contributor.authorBaldassarre, Damiano
dc.contributor.authorBalkau, Beverley
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorBöger, Carsten A.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBouchard, Claude
dc.contributor.authorBruinenberg, Marcel
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorIda Chen, Yii-Der
dc.contributor.authorChines, Peter S.
dc.contributor.authorCooper, Richard S.
dc.contributor.authorCucca, Francesco
dc.contributor.authorCusi, Daniele
dc.contributor.authorDe Faire, Ulf
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorFranks, Paul W.
dc.contributor.authorFroguel, Philippe
dc.contributor.authorGordon-Larsen, Penny
dc.contributor.authorGrabe, Hans Jörgen
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHayward, Caroline
dc.contributor.authorHveem, Kristian
dc.contributor.authorJohnson, Andrew D.
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorKardia, Sharon L.R.
dc.contributor.authorKivimäki, Mika
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorKuh, Diana
dc.contributor.authorLaakso, Markku
dc.contributor.authorLehtimaki, Terho
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorMärz, Winfried
dc.contributor.authorMcCarthy, Mark I.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorOhlsson, Claes
dc.contributor.authorPalmer, Lyle J.
dc.contributor.authorPasterkamp, Gerard
dc.contributor.authorPedersen, Oluf
dc.contributor.authorPeters, Annette
dc.contributor.authorPeters, Ulrike
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorQi, Lu
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorSmith, Blair H.
dc.contributor.authorSørensen, Thorkild I.A.
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorTiemeier, Henning
dc.contributor.authorTremoli, Elena
dc.contributor.authorVan Der Harst, Pim
dc.contributor.authorVestergaard, Henrik
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorWeir, David J.
dc.contributor.authorWhitfield, John B.
dc.contributor.authorWilson, James F.
dc.contributor.authorTyrrell, Jessica
dc.contributor.authorFrayling, Timothy M.
dc.contributor.authorBarroso, Inês
dc.contributor.authorBoehnke, Michael
dc.contributor.authorDeloukas, Panagiotis
dc.contributor.authorFox, Caroline S.
dc.contributor.authorHirschhorn, Joel N.
dc.contributor.authorHunter, David J.
dc.contributor.authorSpector, Tim D.
dc.contributor.authorStrachan, David P.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorHeid, Iris M.
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorMarchini, Jonathan
dc.contributor.authorLoos, Ruth J.F.
dc.contributor.authorKilpeläinen, Tuomas O.
dc.contributor.authorLiu, Ching-Ti
dc.contributor.authorBorecki, Ingrid B.
dc.contributor.authorNorth, Kari E.
dc.contributor.authorCupples, L. Adrienne
dc.date.accessioned2018-06-01T06:03:36Z
dc.date.available2018-06-01T06:03:36Z
dc.date.created2017-10-03T15:46:02Z
dc.date.issued2017
dc.identifier.citationNature Communications. 2017, 8:14977 1-19.nb_NO
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11250/2499974
dc.description.abstractFew genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traitsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-19nb_NO
dc.source.volume8:14977nb_NO
dc.source.journalNature Communicationsnb_NO
dc.identifier.doi10.1038/ncomms14977
dc.identifier.cristin1501931
dc.description.localcodeCopyright The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.nb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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