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dc.contributor.authorRatner, Dmitry
dc.contributor.authorØrning, Mathias Pontus
dc.contributor.authorLien, Egil
dc.date.accessioned2018-04-20T11:09:10Z
dc.date.available2018-04-20T11:09:10Z
dc.date.created2017-01-09T16:09:36Z
dc.date.issued2017
dc.identifier.citationJournal of Leukocyte Biology. 2017, 101 (1), 165-181.nb_NO
dc.identifier.issn0741-5400
dc.identifier.urihttp://hdl.handle.net/11250/2495286
dc.description.abstractInnate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram‐negative bacteria can exhibit specialized nanomachine secretion systems for delivery of effector proteins into mammalian cells. Bacterial types III, IV, and VI secretion systems (T3SS, T4SS, and T6SS) are known for their impact on caspase‐1‐activating inflammasomes, necessary for producing bioactive inflammatory cytokines IL‐1β and IL‐18, key participants of anti‐bacterial responses. Here, we discuss how these secretion systems can mediate triggering and inhibition of inflammasome signaling. We propose that a fine balance between secretion system‐mediated activation and inhibition can determine net activation of inflammasome activity and control inflammation, clearance, or spread of the infection.nb_NO
dc.language.isoengnb_NO
dc.publisherSociety for Leukocyte Biologynb_NO
dc.titleBacterial secretion systems and regulation of inflammasome activationnb_NO
dc.typeJournal articlenb_NO
dc.description.versionsubmittedVersionnb_NO
dc.source.pagenumber165-181nb_NO
dc.source.volume101nb_NO
dc.source.journalJournal of Leukocyte Biologynb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1189/jlb.4MR0716-330R
dc.identifier.cristin1423680
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcodeThis is a submitted manuscript of an article published by Society for Leukocyte Biology in Journal of Leukocyte Biology, 3 November 2016nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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