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dc.contributor.authorHjorth-Hansen, Anna
dc.contributor.authorSalvesen, Øyvind
dc.contributor.authorHanem, Liv Guro Engen
dc.contributor.authorEggebø, Torbjørn Moe
dc.contributor.authorSalvesen, Kjell Å
dc.contributor.authorVanky, Eszter
dc.contributor.authorØdegård, Rønnaug
dc.date.accessioned2018-04-06T10:31:42Z
dc.date.available2018-04-06T10:31:42Z
dc.date.created2018-01-04T11:44:45Z
dc.date.issued2017
dc.identifier.issn0021-972X
dc.identifier.urihttp://hdl.handle.net/11250/2493021
dc.description.abstractContext Metformin is used in an attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS). Little is known about the effect of metformin on fetal development and growth. Objectives To compare the effect of metformin versus placebo on fetal growth and birth anthropometrics in PCOS offspring compared with a reference population in relation to maternal body mass index (BMI). Design Post hoc analysis of a randomized controlled trial. Setting Double-blind, placebo-controlled, multicenter study. Patients 258 offspring born to mothers with PCOS. Intervention 2000 mg metformin (n = 131) or placebo (n = 121) from first trimester to delivery. Main Outcome Measures Mean abdominal diameter and biparietal diameter (BPD) at gestational weeks 19 and 32. Head circumference (HC), birth length, and weight related to a reference population of healthy offspring, expressed as gestational age– and sex-adjusted z-scores. Results Metformin- versus placebo-exposed offspring had larger heads at gestational week 32 (BPD, 86.1 mm versus 85.2 mm; P = 0.03) and at birth (HC, 35.6 cm versus 35.1 cm; P < 0.01). Analyses stratified by maternal prepregnancy BMI, larger heads were observed only among offspring of overweight/obese mothers. Among normal-weight mothers, the effect of metformin compared with placebo was reduced length (z-score = −0.96 versus -0.42, P = 0.04) and weight (z-score = −0.44 versus 0.02; P = 0.03). Compared with the reference population, offspring born to PCOS mothers (placebo group) had reduced length (z-score = −0.40; 95% confidence interval, −0.60 to −0.40), but similar birth weight and HC. Conclusions Metformin exposure resulted in larger head size in offspring of overweight mothers, traceable already in utero. Maternal prepregnancy BMI modified the effect of metformin on offspring anthropometrics. Anthropometrics of offspring born to PCOS mothers differed from those of the reference population.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Press (OUP)nb_NO
dc.titleFetal growth and birth anthropometrics in metformin exposed offspring born to mothers with PCOSnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.journalJournal of Clinical Endocrinology and Metabolismnb_NO
dc.source.issue17nb_NO
dc.identifier.doi10.1210/jc.2017-01191
dc.identifier.cristin1535670
dc.description.localcodeLocked until 17.11.2018 due to copyright restrictions. This is a pre-copyedited, author-produced version of an article accepted for publication in [The Journal of Clinical Endocrinology & Metabolism] following peer review. The version of record is available online at: https://academic.oup.com/jcem/article/103/2/740/4638333nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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