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dc.contributor.authorAlme, Charlotte
dc.contributor.authorMiao, Chenglin
dc.contributor.authorJezek, Karel
dc.contributor.authorTreves, Alessandro
dc.contributor.authorMoser, Edvard Ingjald
dc.contributor.authorMoser, May-Britt
dc.date.accessioned2018-03-23T10:02:39Z
dc.date.available2018-03-23T10:02:39Z
dc.date.created2014-12-09T10:17:49Z
dc.date.issued2014
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2014, 111 (52), 18428-18435.nb_NO
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11250/2491861
dc.description.abstractThe contribution of hippocampal circuits to high-capacity episodic memory is often attributed to the large number of orthogonal activity patterns that may be stored in these networks. Evidence for high-capacity storage in the hippocampus is missing, however. When animals are tested in pairs of environments, different combinations of place cells are recruited, consistent with the notion of independent representations. However, the extent to which representations remain independent across larger numbers of environments has not been determined. To investigate whether spatial firing patterns recur when animals are exposed to multiple environments, we tested rats in 11 recording boxes, each in a different room, allowing for 55 comparisons of place maps in each animal. In each environment, activity was recorded from neuronal ensembles in hippocampal area CA3, with an average of 30 active cells per animal. Representations were highly correlated between repeated tests in the same room but remained orthogonal across all combinations of different rooms, with minimal overlap in the active cell samples from each environment. A low proportion of cells had activity in many rooms but the firing locations of these cells were completely uncorrelated. Taken together, the results suggest that the number of independent spatial representations stored in hippocampal area CA3 is large, with minimal recurrence of spatial firing patterns across environments.nb_NO
dc.language.isoengnb_NO
dc.publisherNational Academy of Sciencesnb_NO
dc.titlePlace cells in the hippocampus: Eleven maps for eleven roomsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber18428-18435nb_NO
dc.source.volume111nb_NO
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americanb_NO
dc.source.issue52nb_NO
dc.identifier.doi10.1073/pnas.1421056111
dc.identifier.cristin1182543
dc.relation.projectEU/268598nb_NO
dc.relation.projectAndre: Kavli Foundationnb_NO
dc.relation.projectNorges forskningsråd: 223262nb_NO
dc.relation.projectNorges forskningsråd: 145993nb_NO
dc.description.localcode© 2014 National Academy of Sciencesnb_NO
cristin.unitcode194,65,60,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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