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dc.contributor.authorBenet-Campos, Carmen
dc.contributor.authorCuéllar, Carmen
dc.contributor.authorGarcía-Ballesteros, Carlos
dc.contributor.authorZamora, Vega
dc.contributor.authorGil-Borrás, Rafael
dc.contributor.authorcatalan-Serra, Ignacio
dc.contributor.authorLópez-Chulía, Francisca
dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.date.accessioned2018-03-21T13:10:26Z
dc.date.available2018-03-21T13:10:26Z
dc.date.created2017-06-15T12:19:52Z
dc.date.issued2017
dc.identifier.citationDigestive Diseases and Sciences. 2017, 62 (4), 934-943.nb_NO
dc.identifier.issn0163-2116
dc.identifier.urihttp://hdl.handle.net/11250/2491508
dc.description.abstractBackground The etiology of Crohn’s disease (CD) is still unknown although new theories are based on defects in innate immunity. We have previously shown a decrease in γδ T cells in CD patients. Previous studies have shown a high prevalence of anti-A. simplex immunoglobulins in CD patients. The diminution of γδ T cells in the peripheral blood and intestinal mucosa of CD patients may create a state of immunosuppression that would facilitate A. simplex infection. Aims To study the antibody responses to Anisakis antigens in Crohn’s disease patients and its relationship with αβ and γδ T cell subsets. Methods We recruited 81 CD patients and 81 healthy controls. αβ and γδ T cell subsets and anti-A. simplex antibodies were measured. Results Levels of anti-A. simplex IgG and IgM were significantly increased in CD patients. Almost 20% of CD patients were positive for IgG and IgM anti-A. simplex versus only 3.7 and 2.5%, respectively, in normal subjects. However, lower specific IgA levels were observed in the group of CD patients versus healthy subjects. We found an association between CD3 + CD8 + γδ subset and IgM anti-A. simplex levels. In ileal cases and stricturing behavior of CD, we observed the highest levels of specific antibodies with the exception of anti-A. simplex IgA. Conclusions The relationship of specific antibodies with a γδ T cell deficiency makes these cell candidates to play a role in the immune response against Anisakis. In addition, anti-Anisakis antibodies could be considered as markers of risk of progression in CD.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Verlagnb_NO
dc.titleDetermination of anti-anisakis simplex antibodies and relationship with αβ and γδ lymphocyte subpopulations in patients with Crohn's Diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber934-943nb_NO
dc.source.volume62nb_NO
dc.source.journalDigestive Diseases and Sciencesnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1007/s10620-017-4473-6
dc.identifier.cristin1476343
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2017 by Springer Verlagnb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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