dc.contributor.author | Benet-Campos, Carmen | |
dc.contributor.author | Cuéllar, Carmen | |
dc.contributor.author | García-Ballesteros, Carlos | |
dc.contributor.author | Zamora, Vega | |
dc.contributor.author | Gil-Borrás, Rafael | |
dc.contributor.author | catalan-Serra, Ignacio | |
dc.contributor.author | López-Chulía, Francisca | |
dc.contributor.author | Andreu-Ballester, Juan Carlos | |
dc.date.accessioned | 2018-03-21T13:10:26Z | |
dc.date.available | 2018-03-21T13:10:26Z | |
dc.date.created | 2017-06-15T12:19:52Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Digestive Diseases and Sciences. 2017, 62 (4), 934-943. | nb_NO |
dc.identifier.issn | 0163-2116 | |
dc.identifier.uri | http://hdl.handle.net/11250/2491508 | |
dc.description.abstract | Background
The etiology of Crohn’s disease (CD) is still unknown although new theories are based on defects in innate immunity. We have previously shown a decrease in γδ T cells in CD patients. Previous studies have shown a high prevalence of anti-A. simplex immunoglobulins in CD patients. The diminution of γδ T cells in the peripheral blood and intestinal mucosa of CD patients may create a state of immunosuppression that would facilitate A. simplex infection.
Aims
To study the antibody responses to Anisakis antigens in Crohn’s disease patients and its relationship with αβ and γδ T cell subsets.
Methods
We recruited 81 CD patients and 81 healthy controls. αβ and γδ T cell subsets and anti-A. simplex antibodies were measured.
Results
Levels of anti-A. simplex IgG and IgM were significantly increased in CD patients. Almost 20% of CD patients were positive for IgG and IgM anti-A. simplex versus only 3.7 and 2.5%, respectively, in normal subjects. However, lower specific IgA levels were observed in the group of CD patients versus healthy subjects. We found an association between CD3 + CD8 + γδ subset and IgM anti-A. simplex levels. In ileal cases and stricturing behavior of CD, we observed the highest levels of specific antibodies with the exception of anti-A. simplex IgA.
Conclusions
The relationship of specific antibodies with a γδ T cell deficiency makes these cell candidates to play a role in the immune response against Anisakis. In addition, anti-Anisakis antibodies could be considered as markers of risk of progression in CD. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Verlag | nb_NO |
dc.title | Determination of anti-anisakis simplex antibodies and relationship with αβ and γδ lymphocyte subpopulations in patients with Crohn's Disease | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 934-943 | nb_NO |
dc.source.volume | 62 | nb_NO |
dc.source.journal | Digestive Diseases and Sciences | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.1007/s10620-017-4473-6 | |
dc.identifier.cristin | 1476343 | |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2017 by Springer Verlag | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |