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dc.contributor.authorWefers, Annika K
dc.contributor.authorHaberlandt, Christian
dc.contributor.authorTekin, Nuriye Basdag
dc.contributor.authorFedorov, D.
dc.contributor.authorTimmermann, A.
dc.contributor.authorVan der Want, Johannes
dc.contributor.authorChaudhry, Farrukh Abbas
dc.contributor.authorSteinhäuser, Christian
dc.contributor.authorSchilling, K
dc.contributor.authorJabs, Ronald
dc.date.accessioned2018-02-20T14:17:46Z
dc.date.available2018-02-20T14:17:46Z
dc.date.created2017-12-20T13:46:34Z
dc.date.issued2017
dc.identifier.citationDevelopment. 2017, 144 (22), 4125-4136.nb_NO
dc.identifier.issn0950-1991
dc.identifier.urihttp://hdl.handle.net/11250/2486054
dc.description.abstractDuring CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal motility include classical neurotransmitters, yet the mechanisms that assure interneuron dispersal and interneuron/projection neuron matching during histogenesis remain largely elusive. We combined time-lapse video microscopy and electrophysiological analysis of the nascent cerebellum of transgenic Pax2-EGFP mice to address this issue. We found that cerebellar interneuronal precursors regularly show spontaneous postsynaptic currents, indicative of synaptic innervation, well before settling in the molecular layer. In keeping with the sensitivity of these cells to neurotransmitters, ablation of synaptic communication by blocking vesicular release in acute slices of developing cerebella slows migration. Significantly, abrogation of exocytosis primarily impedes the directional persistence of migratory interneuronal precursors. These results establish an unprecedented function of the early synaptic innervation of migrating neuronal precursors and demonstrate a role for synapses in the regulation of migration and pathfinding.nb_NO
dc.language.isoengnb_NO
dc.publisherCompany of Biologistsnb_NO
dc.titleSynaptic input as a directional cue for migrating interneuron precursorsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber4125-4136nb_NO
dc.source.volume144nb_NO
dc.source.journalDevelopmentnb_NO
dc.source.issue22nb_NO
dc.identifier.doi10.1242/dev.154096
dc.identifier.cristin1530451
dc.description.localcode© 2017. This is the authors’ accepted and refereed manuscript to the article. Locked until 14.11.2018 due to copyright restrictions.nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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