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dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorStreit, F
dc.contributor.authorJungkunz, M
dc.contributor.authorFrank, J
dc.contributor.authorAwasthi, S
dc.contributor.authorReinbold, CS
dc.contributor.authorTreutlein, J
dc.contributor.authorDegenhardt, F
dc.contributor.authorForstner, AJ
dc.contributor.authorHeilmann-Heimbach, S
dc.contributor.authorDietl, L
dc.contributor.authorSchwarze, CE
dc.contributor.authorSchendel, D
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorAbdellaoui, A
dc.contributor.authorAdolfsson, Rolf
dc.contributor.authorAir, TM
dc.contributor.authorAkil, Huda
dc.contributor.authorAlda, Martin
dc.contributor.authorAlliey-Rodriguez, N
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorBabadjanova, Gulia
dc.contributor.authorBass, N
dc.contributor.authorBauer, M
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBellivier, Frank
dc.contributor.authorBergen, Sarah E
dc.contributor.authorBethell, A
dc.contributor.authorBiernacka, Joanna M.
dc.contributor.authorBlackwood, Douglas H.R.
dc.contributor.authorBoks, Marco P
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBorglum, Anders D
dc.contributor.authorBorrmann-Hassenbach, M
dc.contributor.authorBrennan, P
dc.contributor.authorBudde, M
dc.contributor.authorButtenschon, HN
dc.contributor.authorByrne, Enda M.
dc.contributor.authorCervantes, P
dc.contributor.authorClarke, TK
dc.contributor.authorCraddock, N
dc.contributor.authorCruceanu, C
dc.contributor.authorCurtis, David
dc.contributor.authorCzerski, Piotr M.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDavis, T
dc.contributor.authorde Geus, Eco J C
dc.contributor.authorDi Florio, A
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDomenici, Enrico
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorEtain, Bruno
dc.contributor.authorFischer, SB
dc.contributor.authorForty, L
dc.contributor.authorFraser, C
dc.contributor.authorFrye, M
dc.contributor.authorFullerton, JM
dc.contributor.authorGershon, Elliot S.
dc.contributor.authorGieglin, I
dc.contributor.authorGordon, Scott D
dc.contributor.authorGordon-Smith, K
dc.contributor.authorGrabe, Hans Jörgen
dc.contributor.authorGreen, EK
dc.contributor.authorGreenwood, TA
dc.contributor.authorGrigoroiu-Serbanescu, Maria
dc.contributor.authorGuzman-Parra, J
dc.contributor.authorHall, L
dc.contributor.authorHamshere, Marian
dc.contributor.authorHauser, J
dc.contributor.authorHautzinger, Martin
dc.contributor.authorHeilbronner, U
dc.contributor.authorHerms, Stefan
dc.contributor.authorHitturlingappa, S
dc.contributor.authorHOFFMANN, PAVEL
dc.contributor.authorHolmans, P
dc.contributor.authorHottenga, Jouke Jan
dc.contributor.authorJamain, Stephane
dc.contributor.authorJones, I
dc.contributor.authorJones, L
dc.contributor.authorJuréus, Anna
dc.contributor.authorKahn, René S
dc.contributor.authorKammerer-Ciernioch, Jutta
dc.contributor.authorKirov, George
dc.contributor.authorKittel-Schneider, Sarah
dc.contributor.authorKloiber, Stefan
dc.contributor.authorKnott, SV
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorLanden, M
dc.contributor.authorLeber, M
dc.contributor.authorLeboyer, Marion
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLucae, Susanne
dc.contributor.authorMartin, NG
dc.contributor.authorMayoral-Cleries, F
dc.contributor.authorMcElroy, SL
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMcKay, James D
dc.contributor.authorMcQuilling, A
dc.contributor.authorMedland, Sarah E
dc.contributor.authorMiddeldorp, Christel M.
dc.contributor.authorMilaneschi, Y
dc.contributor.authorMitchell, Philip B
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorMors, O
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorMuller-Myshok, B
dc.contributor.authorMyers, Richard M
dc.contributor.authorNievergelt, Caroline M.
dc.contributor.authorNurnberger, John I.
dc.contributor.authorO'Donovan, Michael C
dc.contributor.authorLoohuis, Loes M. Olde
dc.contributor.authorOphoff, R
dc.contributor.authorOruc, Liliana
dc.contributor.authorOwen, Michael J
dc.contributor.authorPaciga, SA
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPerry, A
dc.contributor.authorPfennig, Andrea
dc.contributor.authorPotash, James B.
dc.contributor.authorPreisig, Martin
dc.contributor.authorReif, A
dc.contributor.authorRivas, F
dc.contributor.authorRouleau, GA
dc.contributor.authorSchofield, Peter R
dc.contributor.authorSchulze, Thomas G
dc.contributor.authorSchwarz, M
dc.contributor.authorScott, L
dc.contributor.authorSinnamon, GCB
dc.contributor.authorStahl, Eli A.
dc.contributor.authorStrauss, J
dc.contributor.authorTurecki, G
dc.contributor.authorVan der Auwera, S
dc.contributor.authorVedder, Helmut
dc.contributor.authorVincent, John B
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWitt, CC
dc.contributor.authorWray, Naomi R
dc.contributor.authorXi, HS
dc.contributor.authorTadic, A
dc.contributor.authorDahmen, Norbert
dc.contributor.authorSchott, Björn H
dc.contributor.authorCichon, Sven
dc.contributor.authorNothen, Markus M
dc.contributor.authorRipke, Stephan
dc.contributor.authorMobascher, A
dc.contributor.authorRujescu, Dan
dc.contributor.authorLieb, K
dc.contributor.authorRoepke, S
dc.contributor.authorSchmal, Christine
dc.contributor.authorBohus, Martin
dc.contributor.authorRietschel, Marcella
dc.contributor.authorMorken, Gunnar
dc.contributor.authorGade, K
dc.date.accessioned2018-02-12T12:16:35Z
dc.date.available2018-02-12T12:16:35Z
dc.date.created2018-01-31T13:16:11Z
dc.date.issued2017
dc.identifier.citationTranslational psychiatry. 2017, 7 (6), e1155-?.nb_NO
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/11250/2484088
dc.description.abstractBorderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57 [P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537640/
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenianb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume7nb_NO
dc.source.journalTranslational psychiatrynb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.1038/tp.2017.115
dc.identifier.cristin1558577
dc.relation.projectNorges forskningsråd: 223273nb_NO
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-008nb_NO
dc.description.localcode© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)nb_NO
cristin.unitcode194,65,35,0
cristin.unitnameInstitutt for psykisk helse
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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