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dc.contributor.authorLu, Yunxia
dc.contributor.authorNess-Jensen, Eivind
dc.contributor.authorHveem, Kristian
dc.contributor.authorMartling, Anna
dc.date.accessioned2018-02-08T16:45:48Z
dc.date.available2018-02-08T16:45:48Z
dc.date.created2015-11-06T06:30:39Z
dc.date.issued2015
dc.identifier.citationAmerican Journal of Epidemiology. 2015, 182 (10), 883-893.nb_NO
dc.identifier.issn0002-9262
dc.identifier.urihttp://hdl.handle.net/11250/2483625
dc.description.abstractWhether different definitions of metabolic syndrome (MetS) are differently associated with colorectal adenocarcinoma (CA) by anatomical location is unclear. A population-based cohort study, the Cohort of Norway (CONOR) Study, was conducted in Norway from 1995 to 2010. Anthropometric measurements, blood samples, and lifestyle data were collected at recruitment. CAs were identified through linkage to the Norwegian Cancer Register. A composite index of MetS as defined by the International Diabetes Federation (IDF) or/and the National Cholesterol Education Program's Adult Treatment Panel III (ATP III) and single components of MetS, including anthropometric factors, blood pressure, lipids, triglycerides, and glucose, were analyzed. Cox proportional hazards regression was performed to estimate hazard ratios and 95% confidence intervals. Significant associations between single MetS components and CA, except for reduced high-density lipoprotein cholesterol and nonfasting glucose levels, were observed. MetS defined by 2 criteria separately showed a similar association with CA in general, and MetS defined by both the IDF and ATP III showed consistent results. Stronger associations were observed in the proximal colon among men (IDF: hazard ratio (HR) = 1.51, 95% confidence interval (CI): 1.24, 1.84; ATP III: HR = 1.40, 95% CI: 1.15, 1.70) and in the rectum among women (IDF: HR = 1.42, 95% CI: 1.07, 1.89; ATP III: HR = 1.43, 95% CI: 1.08, 1.90).nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Pressnb_NO
dc.relation.urihttp://aje.oxfordjournals.org/content/182/10/883.full.pdf+html
dc.titleMetabolic predispositions and increased risk of colorectal adenocarcinoma by anatomical location: a large population-based cohort study in Norwaynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber883-893nb_NO
dc.source.volume182nb_NO
dc.source.journalAmerican Journal of Epidemiologynb_NO
dc.source.issue10nb_NO
dc.identifier.doi10.1093/aje/kwv141
dc.identifier.cristin1286730
dc.description.localcode© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. This is a pre-copyedited, author-produced version of the article accepted for publication following peer review. The version of record is available online at: http://dx.doi.org/10.1093/aje/kwv141.nb_NO
cristin.unitcode194,65,20,15
cristin.unitcode194,65,20,0
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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