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dc.contributor.authorTanskanen, Tomas
dc.contributor.authorVan Den Berg, Linda
dc.contributor.authorVälimäki, Niko
dc.contributor.authorAavikko, Mervi
dc.contributor.authorNess-Jensen, Eivind
dc.contributor.authorHveem, Kristian
dc.contributor.authorWettergren, Yvonne
dc.contributor.authorLindskog, Elinor Bexe
dc.contributor.authorTönisson, Neeme
dc.contributor.authorMetspalu, Andres
dc.contributor.authorSilander, Kaisa
dc.contributor.authorOrlando, Giulia
dc.contributor.authorLaw, Philip J.
dc.contributor.authorTuupanen, Sari
dc.contributor.authorGylfe, Alexandra E.
dc.contributor.authorHänninen, Ulrika A.
dc.contributor.authorCajuso, Tatiana
dc.contributor.authorKondelin, Johanna
dc.contributor.authorSarin, Antti-Pekka
dc.contributor.authorPukkala, Eero
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorRipatti, Samuli
dc.contributor.authorPalotie, Aarno
dc.contributor.authorJärvinen, Heikki
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorLepistö, Anna
dc.contributor.authorBöhm, Jan
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorAl-Tassan, Nada A.
dc.contributor.authorPalles, Claire
dc.contributor.authorMartin, Lynn
dc.contributor.authorBarclay, Ella
dc.contributor.authorTenesa, Albert
dc.contributor.authorFarrington, Susan M.
dc.contributor.authorTimofeeva, Maria N.
dc.contributor.authorMeyer, Brian F
dc.contributor.authorWakil, Salma M.
dc.contributor.authorCampbell, Harry
dc.contributor.authorSmith, Christopher G.
dc.contributor.authorIdziaszczyk, Shelley
dc.contributor.authorMaughan, Tim S.
dc.contributor.authorKaplan, Richard
dc.contributor.authorKerr, Rachel
dc.contributor.authorKerr, David
dc.contributor.authorBuchanan, Daniel D.
dc.contributor.authorWin, Aung K.
dc.contributor.authorHopper, John
dc.contributor.authorJenkins, Mark A.
dc.contributor.authorNewcomb, Polly A.
dc.contributor.authorGallinger, Steve
dc.contributor.authorConti, David
dc.contributor.authorSchumacher, Fredrick R.
dc.contributor.authorCasey, Graham
dc.contributor.authorCheadle, Jeremy P.
dc.contributor.authorDunlop, Malcolm G.
dc.contributor.authorTomlinson, Ian P
dc.contributor.authorHoulston, Richard S.
dc.contributor.authorPalin, Kimmo
dc.contributor.authorAaltonen, Lauri
dc.date.accessioned2018-02-08T09:58:37Z
dc.date.available2018-02-08T09:58:37Z
dc.date.created2018-01-02T19:52:06Z
dc.date.issued2018
dc.identifier.citationInternational Journal of Cancer. 2018, 142 (3), 540-546.nb_NO
dc.identifier.issn0020-7136
dc.identifier.urihttp://hdl.handle.net/11250/2483441
dc.description.abstractGenome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10−4; OR, 1.14; 95% CI, 1.06–1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10−9; OR, 1.12; 95% CI, 1.08–1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titleGenome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk locinb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber540-546nb_NO
dc.source.volume142nb_NO
dc.source.journalInternational Journal of Cancernb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.1002/ijc.31076
dc.identifier.cristin1534211
dc.description.localcode© 2017 UICC. This is the peer reviewed version of the article locked until 7 December 2018 due to copyright restirctions, which has been published in final form at http://dx.doi.org/10.1002/ijc.31076. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.nb_NO
cristin.unitcode194,65,20,15
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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