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dc.contributor.authorde Rodez Benavent, Sigrid Aune
dc.contributor.authorNygaard, Gro Owren
dc.contributor.authorHarbo, Hanne
dc.contributor.authorTønnesen, Siren
dc.contributor.authorSowa, Piotr
dc.contributor.authorLandrø, Nils Inge
dc.contributor.authorGustavsen, Marte Wendel
dc.contributor.authorEtholm, Lars
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorDrolsum, Liv
dc.contributor.authorKerty, Emilia
dc.contributor.authorCelius, Elisabeth Gulowsen
dc.contributor.authorLaeng, Bruno
dc.date.accessioned2018-02-05T16:09:06Z
dc.date.available2018-02-05T16:09:06Z
dc.date.created2017-06-01T12:49:00Z
dc.date.issued2017
dc.identifier.citationBrain and Behavior. 2017, 7 (7).nb_NO
dc.identifier.issn2162-3279
dc.identifier.urihttp://hdl.handle.net/11250/2482805
dc.description.abstractIntroduction In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function. Methods This study assesses pupil size during problem-solving in early MS patients versus controls. A difference in pupil size to a cognitive challenge could signal altered activity within the autonomic system because of early functional brain changes associated with cognitive load. We recruited MS patients (mean disease duration: 2.6 years, N = 41) and age-matched healthy controls (N = 43) without eye pathology. Neurological impairment, magnetic resonance imaging, visual evoked potentials, depression, and fatigue were assessed in all of the patients. In both groups, we assessed processing speed and retinal imaging. Pupil size was recorded with an eye-tracker during playback of multiplication tasks. Results Both groups performed well on the cognitive test. The groups showed similar pupillary responses with a mean of 0.55 mm dilation in patients and 0.54 mm dilation in controls for all the tasks collapsed together. However, controls (N = 9) with low cognitive scores (LCS) had an increased pupillary response to cognitive tasks, whereas LCS MS patients (N = 6) did not (p < .05). There was a tendency toward a smaller pupillary response in patients with fatigue. Conclusions This is the first study to investigate pupillary responses to cognitive tasks in MS patients. Our results suggest that MS-related changes in cognition and fatigue may be associated with changes in arousal and the autonomic regulation of task-related pupillary responses. This supports the theory of a link between cognition and fatigue in MS.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleFatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patientsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber12nb_NO
dc.source.volume7nb_NO
dc.source.journalBrain and Behaviornb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1002/brb3.717
dc.identifier.cristin1473480
dc.description.localcode© 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitcode194,65,30,0
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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