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dc.contributor.authorHofmann, Bjørn
dc.date.accessioned2018-02-05T12:03:35Z
dc.date.available2018-02-05T12:03:35Z
dc.date.created2017-01-20T10:21:45Z
dc.date.issued2017
dc.identifier.citationJournal of Evaluation In Clinical Practice. 2017, 23 (3), 631-641.nb_NO
dc.identifier.issn1356-1294
dc.identifier.urihttp://hdl.handle.net/11250/2482616
dc.description.abstractRationale, aims, and objectives Colorectal cancer (CRC) screening is widely recommended and implemented. However, sometimes CRC screening is not implemented despite good evidence, and some types of CRC screening are implemented despite lack of evidence. The objective of this article is to expose and elucidate relevant ethical issues in the literature on CRC screening that are important for open and transparent deliberation on CRC screening. Methods An axiological question-based method is used for exposing and elucidating ethical issues relevant in HTA. A literature search in MEDLINE, Embase, PsycINFO, PubMed Bioethics subset, ISI Web of Knowledge, Bioethics Literature Database (BELIT), Ethics in Medicine (ETHMED), SIBIL Base dati di bioetica, LEWI Bibliographic Database on Ethics in the Sciences and Humanities, and EUROETHICS identified 870 references of which 114 were found relevant according to title and abstract. The content of the included papers were subject to ethical analysis to highlight the ethical issues, concerns, and arguments. Results A wide range of important ethical issues were identified. The main benefits are reduced relative CRC mortality rate, and potentially incidence rate, but there is no evidence of reduced absolute mortality rate. Potential harms are bleeding, perforation, false test results, overdetection, overdiagnosis, overtreatment (including unnecessary removal of polyps), and (rarely) death. Other important issues are related to autonomy and informed choice equity, justice, medicalization, and expanding disease. Conclusion A series of important ethical issues have been identified and need to be addressed in open and transparent deliberation on CRC screening.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titleEthical issues with colorectal cancer screening—a systematic reviewnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber631-641nb_NO
dc.source.volume23nb_NO
dc.source.journalJournal of Evaluation In Clinical Practicenb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.1111/jep.12690
dc.identifier.cristin1433238
dc.description.localcodeThis is the peer reviewed version of the following article: Hofmann B. Ethical issues with colorectal cancer screening—a systematic review. J Eval Clin Pract. 2017;23:631–641, which has been published in final form at https://doi.org/10.1111/jep.12690. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.nb_NO
cristin.unitcode194,65,70,0
cristin.unitnameInstitutt for helsevitenskap Gjøvik
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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