dc.contributor.author | Snekvik, Ingrid | |
dc.contributor.author | Smith, Catherine H. | |
dc.contributor.author | Nilsen, Tom Ivar Lund | |
dc.contributor.author | Langan, Sinéad M. | |
dc.contributor.author | Modalsli, Ellen Heilmann | |
dc.contributor.author | Romundstad, Pål Richard | |
dc.contributor.author | Saunes, Marit | |
dc.date.accessioned | 2018-01-23T09:49:28Z | |
dc.date.available | 2018-01-23T09:49:28Z | |
dc.date.created | 2017-12-22T10:10:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Journal of Investigative Dermatology. 2017, 137 (12), 2484-2490. | nb_NO |
dc.identifier.issn | 0022-202X | |
dc.identifier.uri | http://hdl.handle.net/11250/2478965 | |
dc.description.abstract | Although psoriasis has been associated with obesity, there are few prospective studies with objective measures. We prospectively examined the effect of body mass index, waist circumference, waist-hip ratio, and 10-year weight change on the risk of developing psoriasis among 33,734 people in the population-based Nord-Trøndelag Health Study (i.e., HUNT), Norway. During follow-up, 369 incident psoriasis cases occurred. Relative risk (RR) of psoriasis was estimated by Cox regression. One standard deviation higher body mass index, waist circumference, and waist-hip ratio gave RRs of 1.22 (95% confidence interval [CI] = 1.11–1.34), 1.26 (95% CI = 1.15–1.39), and 1.18 (95% CI = 1.07–1.31), respectively. Compared with normal weight participants, obese people had an RR of 1.87 (95% CI = 1.38–2.52), whereas comparing the fourth with the first quartile of waist circumference gave an RR of 1.95 (95% CI = 1.46–2.61). One standard deviation higher weight change gave an RR of 1.20 (95% CI = 1.07–1.35), and people who increased their body weight by 10 kg or more had an RR of 1.72 (95% CI = 1.15–2.58) compared with being weight stable. In conclusion, obesity and high abdominal fat mass doubles the risk of psoriasis, and long-term weight gain substantially increases psoriasis risk. Preventing weight gain and promoting maintenance of a normal body weight could reduce incidence of psoriasis. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Obesity, waist circumference, weight change, and risk of incident psoriasis: prospective data from the HUNT study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 2484-2490 | nb_NO |
dc.source.volume | 137 | nb_NO |
dc.source.journal | Journal of Investigative Dermatology | nb_NO |
dc.source.issue | 12 | nb_NO |
dc.identifier.doi | 10.1016/j.jid.2017.07.822 | |
dc.identifier.cristin | 1531364 | |
dc.description.localcode | © 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |