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dc.contributor.authorKirkhus, Lene
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorKristjansson, Siri Rostoft
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorSelbæk, Geir
dc.contributor.authorWyller, Torgeir Bruun
dc.contributor.authorHarneshaug, Magnus
dc.contributor.authorJordhøy, Marit Slaaen
dc.date.accessioned2018-01-19T16:06:44Z
dc.date.available2018-01-19T16:06:44Z
dc.date.created2017-07-12T13:07:04Z
dc.date.issued2017
dc.identifier.citationBritish Journal of Cancer. 2017, 117 (4), 470-477.nb_NO
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/11250/2478443
dc.description.abstractBackground: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ability to identify frailty is scarcely investigated. Methods: We compared oncologists’ classification of frailty (onc-frail) based on clinical judgement with a modified geriatric assessment (mGA), and investigated associations between frailty and overall survival. Patients X70 years referred for medical cancer treatment were eligible. mGA-frailty was defined as impairment in at least one of the following: daily activities, comorbidity, polypharmacy, physical function or at least one geriatric syndrome (cognitive impairment, depression, malnutrition, falls). Results: Three hundred and seven patients were enroled, 288 (94%) completed the mGA, 286 (93%) were rated by oncologists. Median age was 77 years, 56% had metastases, 85% performance status (PS) 0–1. Overall, 104/286 (36%) were onc-frail and 140/288 (49%) mGA-frail, the agreement was fair (kappa value 0.30 (95% CI 0.19; 0.41)), and 67 mGA-frail patients who frequently had localised disease, good PS and received curative treatment, were missed by the oncologists. Only mGA-frailty was independently prognostic for survival (HR 1.61, 95% CI 1.14; 2.27; P¼0.007). Conclusions: Systematic assessment of geriatric domains is needed to aid oncologists in identifying frail patients with poor survival.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Naturenb_NO
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.titleGeriatric assessment is superior to oncologists’ clinical judgement in identifying frailtynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber470-477nb_NO
dc.source.volume117nb_NO
dc.source.journalBritish Journal of Cancernb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1038/bjc.2017.202
dc.identifier.cristin1482034
dc.description.localcodeCopyright The Author(s) 2017. This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-sa/4.0/.nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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