Vis enkel innførsel

dc.contributor.authorQian, Peng
dc.contributor.authorSchork, Andrew J.
dc.contributor.authorBartsch, Hauke
dc.contributor.authorLo, Min-Tzu
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorKremen, William S.
dc.contributor.authorJernigan, Terry L.
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorSteen, Vidar Martin
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorHuentelman, Matt
dc.contributor.authorHåberg, Asta
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorDale, Anders
dc.contributor.authorSchork, Nicholas J.
dc.contributor.authorChen, Chi-Hua
dc.identifier.citationPLoS Genetics. 2016, 12 (7), e1006143.nb_NO
dc.description.abstractThe many subcomponents of the human cortex are known to follow an anatomical pattern and functional relationship that appears to be highly conserved between individuals. This suggests that this pattern and the relationship among cortical regions are important for cortical function and likely shaped by genetic factors, although the degree to which genetic factors contribute to this pattern is unknown. We assessed the genetic relationships among 12 cortical surface areas using brain images and genotype information on 2,364 unrelated individuals, brain images on 466 twin pairs, and transcriptome data on 6 postmortem brains in order to determine whether a consistent and biologically meaningful pattern could be identified from these very different data sets. We find that the patterns revealed by each data set are highly consistent (p<10−3), and are biologically meaningful on several fronts. For example, close genetic relationships are seen in cortical regions within the same lobes and, the frontal lobe, a region showing great evolutionary expansion and functional complexity, has the most distant genetic relationship with other lobes. The frontal lobe also exhibits the most distinct expression pattern relative to the other regions, implicating a number of genes with known functions mediating immune and related processes. Our analyses reflect one of the first attempts to provide an assessment of the biological consistency of a genetic phenomenon involving the brain that leverages very different types of data, and therefore is not just statistical replication which purposefully use very similar data sets.nb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleConservation of Distinct Genetically-Mediated Human Cortical Patternnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalPLoS Geneticsnb_NO
dc.relation.projectNorges forskningsråd: 223273nb_NO
dc.description.localcode© 2016 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal