dc.contributor.author | Gansmo, Liv Beathe | |
dc.contributor.author | Bjørnslett, Merete Pauline | |
dc.contributor.author | Halle, Mari Kyllesø | |
dc.contributor.author | Salvesen, Helga | |
dc.contributor.author | Romundstad, Pål Richard | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Vatten, Lars Johan | |
dc.contributor.author | Dørum, Anne | |
dc.contributor.author | Lønning, Per Eystein | |
dc.contributor.author | Knappskog, Stian | |
dc.date.accessioned | 2018-01-02T14:06:45Z | |
dc.date.available | 2018-01-02T14:06:45Z | |
dc.date.created | 2017-05-13T12:47:51Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | BMC Cancer. 2017, 17:97, 1-6. | nb_NO |
dc.identifier.issn | 1471-2407 | |
dc.identifier.uri | http://hdl.handle.net/11250/2474105 | |
dc.description.abstract | Background
The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact of MDM2 del1518 on risk of ovarian and endometrial cancer.
Methods
Here, we genotyped del1518 in two large hospital-based series of patients diagnosed with ovarian (n = 1,385) or endometrial (n = 1,404) cancer and performed risk estimations as compared to the genotype distribution among 1,872 healthy female controls.
Results
In overall analysis we observed no association between del1518 and risk of either ovarian or endometrial cancer. However, stratifying according to SNP309 status, we found the del1518 variant to be associated with a reduced risk of endometrial cancer among individuals carrying the SNP309TT genotype both in the dominant (OR = 0.64; 95% CI = 0.45 – 0.90) and the recessive model (OR = 0.80; 95% CI = 0.65 – 1.00). No such association was observed for ovarian cancer risk.
Conclusion
We found the MDM2 del1518 del variant to be associated with reduced risk of endometrial cancer among individuals carrying the MDM2 SNP309TT genotype. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BioMed Central | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-6 | nb_NO |
dc.source.volume | 17:97 | nb_NO |
dc.source.journal | BMC Cancer | nb_NO |
dc.identifier.doi | 10.1186/s12885-017-3094-y | |
dc.identifier.cristin | 1470064 | |
dc.relation.project | Norges forskningsråd: 220964 | nb_NO |
dc.description.localcode | le at the end of the article © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |