Show simple item record

dc.contributor.authorSkjaervold, Nils Kristian
dc.contributor.authorØstling, Dan
dc.contributor.authorHjelme, Dag Roar
dc.contributor.authorSpigset, Olav
dc.contributor.authorLyng, Oddveig
dc.contributor.authorAadahl, Petter
dc.identifier.citationInternational Journal of Endocrinology. 2013, Article ID 245152.nb_NO
dc.description.abstractThe aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5–6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.nb_NO
dc.publisherHindawi Publishing Corporationnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBlood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreasnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalInternational Journal of Endocrinologynb_NO
dc.description.localcodeCopyright © 2013 Nils K. Skjaervold et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for elektroniske systemer
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameMH fakultetsadministrasjon

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal