dc.contributor.author | Holien, Toril | |
dc.contributor.author | Sundan, Anders | |
dc.date.accessioned | 2017-12-12T09:12:30Z | |
dc.date.available | 2017-12-12T09:12:30Z | |
dc.date.created | 2014-12-30T17:25:04Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Cytokine & growth factor reviews. 2014, 25 (3), 343-350. | nb_NO |
dc.identifier.issn | 1359-6101 | |
dc.identifier.uri | http://hdl.handle.net/11250/2470556 | |
dc.description.abstract | Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are important for several aspects of myeloma pathogenesis including growth and survival of tumor cells, bone homeostasis, and anemia. Among cancer cells, myeloma cells are particularly sensitive to growth inhibition and apoptosis induced by BMPs and therefore represent good models to study BMP receptor usage and signaling. Our review highlights and discusses the current knowledge on BMP signaling in myeloma. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.title | The role of bone morphogenetic proteins in myeloma cell survival | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | submittedVersion | nb_NO |
dc.source.pagenumber | 343-350 | nb_NO |
dc.source.volume | 25 | nb_NO |
dc.source.journal | Cytokine & growth factor reviews | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.1016/j.cytogfr.2014.04.009 | |
dc.identifier.cristin | 1189328 | |
dc.relation.project | Norges forskningsråd: 223255 | nb_NO |
dc.description.localcode | © 2014 The authors. This document is the Author's version of a submitted work that was subsequently accepted for publication after peer review. To access the final edited and published work see http://dx.doi.org/10.1016/j.cytogfr.2014.04.009 | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |