dc.contributor.author | Paulus, Constanze | |
dc.contributor.author | Rebets, Yuriy | |
dc.contributor.author | Tokovenko, Bogdan | |
dc.contributor.author | Nadmid, Suvd | |
dc.contributor.author | Terekhova, Larisa P. | |
dc.contributor.author | Myronovskyi, Maksym | |
dc.contributor.author | Zotchev, Sergey | |
dc.contributor.author | Rückert, Christian | |
dc.contributor.author | Braig, Simone | |
dc.contributor.author | Zahler, Stefan | |
dc.contributor.author | Kalinowski, Jörn | |
dc.contributor.author | Luzhetskyy, Andriy | |
dc.date.accessioned | 2017-11-27T09:17:47Z | |
dc.date.available | 2017-11-27T09:17:47Z | |
dc.date.created | 2017-07-27T17:33:25Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Scientific Reports. 2017, 7:42382 1-11. | nb_NO |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/11250/2468097 | |
dc.description.abstract | Marine actinobacteria are drawing more and more attention as a promising source of new natural products. Here we report isolation, genome sequencing and metabolic profiling of new strain Streptomyces sp. MP131-18 isolated from marine sediment sample collected in the Trondheim Fjord, Norway. The 16S rRNA and multilocus phylogenetic analysis showed that MP131-18 belongs to the genus Streptomyces. The genome of MP131-18 isolate was sequenced, and 36 gene clusters involved in the biosynthesis of 18 different types of secondary metabolites were predicted using antiSMASH analysis. The combined genomics-metabolics profiling of the strain led to the identification of several new biologically active compounds. As a result, the family of bisindole pyrroles spiroindimicins was extended with two new members, spiroindimicins E and F. Furthermore, prediction of the biosynthetic pathway for unusual α-pyrone lagunapyrone isolated from MP131-18 resulted in foresight and identification of two new compounds of this family – lagunapyrones D and E. The diversity of identified and predicted compounds from Streptomyces sp. MP131-18 demonstrates that marine-derived actinomycetes are not only a promising source of new natural products, but also represent a valuable pool of genes for combinatorial biosynthesis of secondary metabolites. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Publishing Group | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18 | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-11 | nb_NO |
dc.source.volume | 7:42382 | nb_NO |
dc.source.journal | Scientific Reports | nb_NO |
dc.identifier.doi | 10.1038/srep42382 | |
dc.identifier.cristin | 1483246 | |
dc.description.localcode | © 2017 The Authors. Published by Nature Publishing Group. This is an open access article licensed under a Creative Commons Attribution 4.0 International License | nb_NO |
cristin.unitcode | 194,66,15,0 | |
cristin.unitname | Institutt for bioteknologi og matvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |