Vis enkel innførsel

dc.contributor.authorKvaløy, Kirsti
dc.contributor.authorKulle, Bettina
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorHolmen, Turid Lingaas
dc.date.accessioned2017-11-17T09:54:19Z
dc.date.available2017-11-17T09:54:19Z
dc.date.created2013-11-22T14:52:01Z
dc.date.issued2013
dc.identifier.citationInternational Journal of Obesity. 2013, 37 (9), 1221-1229.nb_NO
dc.identifier.issn0307-0565
dc.identifier.urihttp://hdl.handle.net/11250/2466851
dc.description.abstractObjective: The impact of previously identified genetic variants directly or indirectly associated with obesity, were investigated at birth, adolescence and adulthood to provide knowledge concerning timing and mechanisms of obesity susceptibility with focus on sex differences. Design: Twenty four previously identified obesity- and eating disorder susceptibility loci were tested for association with adiposity traits at birth (ponderal index (PI)), adolescence and young adulthood (body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR)) in 1782 individuals from the HUNT study. Single-nucleotide polymorphism (SNPs) were evaluated individually and by haplotype sliding-window approach for windows⩽50 kb (near-MC4R, FTO and near-BDNF). The analyses were performed on the total and sex stratified samples. Results: The most substantial effect on BMI was observed for the near-MC4R variants at adolescence and adulthood (adjusted P-values in adolescence: 0.002 and 0.003 for rs17782313 and rs571312, respectively). The same variants showed inverse association with PI in males (adjusted P-values: 0.019–0.036). Furthermore, significant effects were observed at adolescence with BMI for the near-KCTD15 variant (rs11084753) (adjusted P=0.038) in the combined sample. The near-INSIG2 (rs7566605) was significantly associated to WHR in males and near-BDNF (rs925946) in the combined sample (adjusted P=0.027 and P=0.033, respectively). The OPRD1 locus was associated to BMI and WC in males both at adolescence and adulthood with highest effect in adults (adjusted P=0.058). Interaction with sex was identified for near-MC4R, OPRD1, COMT, near-BDNF and DRD2. Conclusions: Most obesity susceptibility variants show stronger effect at adolescence than at birth and adulthood with a clear sex-specific effect at some loci. The near-MC4R locus exhibit inverse effect on weight at birth in boys compared with findings at adolescence and adulthood. Some variants less known for obesity-susceptibility such as OPRD1 were found to be associated to weight with strongest effects in males.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.titleSex-specific effects of weight-affecting gene variants in a life course perspective-The HUNT Study, Norwaynb_NO
dc.typeJournal articlenb_NO
dc.description.versionsubmittedVersionnb_NO
dc.source.pagenumber1221-1229nb_NO
dc.source.volume37nb_NO
dc.source.journalInternational Journal of Obesitynb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1038/ijo.2012.220
dc.identifier.cristin1068463
dc.description.localcodeThis is a submitted manuscript of an article published by Nature Publishing Group in International Journal of Obesity, 15 January 2013nb_NO
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel