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dc.contributor.authorBolstad, Geir Hysing
dc.contributor.authorCassara, Jason A.
dc.contributor.authorMarquez, Eladio
dc.contributor.authorHansen, Thomas F
dc.contributor.authorvan der Linde, Kim
dc.contributor.authorHoule, David
dc.contributor.authorPelabon, Christophe
dc.date.accessioned2017-11-03T07:10:57Z
dc.date.available2017-11-03T07:10:57Z
dc.date.created2015-09-18T15:01:26Z
dc.date.issued2015
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2015, 112 (43), 13284-13289.nb_NO
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11250/2463865
dc.description.abstractPrecise exponential scaling with size is a fundamental aspect of phenotypic variation. These allometric power laws are often invariant across taxa and have long been hypothesized to reflect developmental constraints. Here we test this hypothesis by investigating the evolutionary potential of an allometric scaling relationship in drosophilid wing shape that is nearly invariant across 111 species separated by at least 50 million years of evolution. In only 26 generations of artificial selection in a population of Drosophila melanogaster, we were able to drive the allometric slope to the outer range of those found among the 111 sampled species. This response was rapidly lost when selection was suspended. Only a small proportion of this reversal could be explained by breakup of linkage disequilibrium, and direct selection on wing shape is also unlikely to explain the reversal, because the more divergent wing shapes produced by selection on the allometric intercept did not revert. We hypothesize that the reversal was instead caused by internal selection arising from pleiotropic links to unknown traits. Our results also suggest that the observed selection response in the allometric slope was due to a component expressed late in larval development and that variation in earlier development did not respond to selection. Together, these results are consistent with a role for pleiotropic constraints in explaining the remarkable evolutionary stability of allometric scaling. allometry | artificial selection | comparative analyses | developmental constraints | pleiotropynb_NO
dc.language.isoengnb_NO
dc.publisherNational Academy of Sciencesnb_NO
dc.titleComplex constraints on allometry revealed by artificial selection on the wing of Drosophila melanogasternb_NO
dc.typeJournal articlenb_NO
dc.description.versionsubmittedVersionnb_NO
dc.source.pagenumber13284-13289nb_NO
dc.source.volume112nb_NO
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americanb_NO
dc.source.issue43nb_NO
dc.identifier.doi10.1073/pnas.1505357112
dc.identifier.cristin1265580
dc.relation.projectNorges forskningsråd: 196434nb_NO
dc.relation.projectNorges forskningsråd: 179569nb_NO
dc.relation.projectNorges forskningsråd: 223257nb_NO
dc.description.localcodeThis is a submitted manuscript of an article published by National Academy of Sciences in Proceedings of the National Academy of Sciences, September 14, 2015nb_NO
cristin.unitcode194,66,10,0
cristin.unitnameInstitutt for biologi
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode2


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