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dc.contributor.authorcatalan-Serra, Ignacio
dc.contributor.authorSandvik, Arne Kristian
dc.contributor.authorBruland, Torunn
dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.date.accessioned2017-11-02T10:01:56Z
dc.date.available2017-11-02T10:01:56Z
dc.date.created2017-04-25T16:43:08Z
dc.date.issued2017
dc.identifier.citationJournal of Crohn's and Colitis. 2017, 1-11.nb_NO
dc.identifier.issn1197-4982
dc.identifier.urihttp://hdl.handle.net/11250/2463653
dc.description.abstractCrohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. An altered immune response to commensal intestinal bacteria takes place in genetically predisposed individuals, resulting in chronic inflammation in the gut. Several alterations in the innate immunity mechanisms have been described in recent years. Thus, the study of the immunological aspects of CD, specifically the role of lymphocytes, is a key element for understanding the pathogenesis of the disease. Gammadelta T cells (γδ T cells) constitute only a small proportion of the lymphocytes that circulate in the blood and peripheral organs and they are present mainly in the epithelia, where they can constitute up to 40% of intraepithelial lymphocytes (IEL) in the intestinal mucosa. Due to their lack of MHC restriction and their unique plasticity and immune regulating properties they are considered key cells in the first line of defense against infections and in wound healing in the gut. Although there is growing experimental and clinical evidence of their implication in inflammatory bowel disease (IBD), including CD, their clinical relevance is still unclear. In this review, we address the possible involvement of γδ T cells in the pathogenesis of CD, reviewing their role against infections and in inflammation and the current evidence suggesting their implication in CD, offering a novel potential target for immunotherapy in IBD.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Press (OUP)nb_NO
dc.titleGammadelta T cells in Crohn's disease: a new player in the disease pathogenesis?nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1-11nb_NO
dc.source.journalJournal of Crohn's and Colitisnb_NO
dc.identifier.doi10.1093/ecco-jcc/jjx039
dc.identifier.cristin1466544
dc.description.localcode© The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the European Crohn's and Colitis Organisation (ECCO). This is the authors' accepted and refereed manuscript to the article. Locked until 16.3.2018 due to copyright restrictionsnb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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