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dc.contributor.authorRivera, A
dc.contributor.authorValdes, L
dc.contributor.authorJimenez, J
dc.contributor.authorPerez, I
dc.contributor.authorLam, A
dc.contributor.authorAltshuler, E
dc.contributor.authorDe Menorval, LC
dc.contributor.authorFossum, Jon Otto
dc.contributor.authorHansen, Elisabeth Lindbo
dc.contributor.authorRozynek, Zbigniew Jerzy
dc.date.accessioned2017-11-02T08:15:26Z
dc.date.available2017-11-02T08:15:26Z
dc.date.created2016-09-30T15:53:29Z
dc.date.issued2016
dc.identifier.citationApplied Clay Science. 2016, 124-125 150-156.nb_NO
dc.identifier.issn0169-1317
dc.identifier.urihttp://hdl.handle.net/11250/2463595
dc.description.abstractClays have shown to be good candidates as drug delivery carriers. In the present paper, the temperature-dependent swelling of smectites was exploited to obtain composites able to release a drug in a controlled way. More specifically, synthetic fluorohectorite-ciprofloxacin composites were prepared, in which the drug molecules were intercalated between the clay layers. The drug-release systems were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermal gravimetric analysis (TGA), ultraviolet spectroscopy (UV) and atomic absorption spectrometry (AAS). The results from the X-ray diffraction allowed confirming the ciprofloxacin incorporation into the interlayer space, and the results from UV spectroscopy indicated that more than 90% of the initial drug was uptaken by the clay. The thermally activated drug release from a colloidal dispersion of nanosized composite particles in both pure water and synthetic gastric juice was evaluated at temperatures from 37 °C (body temperature) to 85 °C. The studies indicated that the clay promotes the slow release of ciprofloxacin, and that the release of drug increases with both time and temperature. The profiles of drug-release from the clay fulfilled the pharmaceutical standards for these systems. As a result, a clay-based Temperature-Controlled Release System (TCRS) with potential biomedical applications has been obtained.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.titleSmectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release propertiesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionsubmittedVersionnb_NO
dc.source.pagenumber150-156nb_NO
dc.source.volume124-125nb_NO
dc.source.journalApplied Clay Sciencenb_NO
dc.identifier.doi10.1016/j.clay.2016.02.006
dc.identifier.cristin1388394
dc.relation.projectNorges forskningsråd: 228551nb_NO
dc.description.localcodeThis is the authors' manuscript to the article (preprint).nb_NO
cristin.unitcode194,66,20,0
cristin.unitnameInstitutt for fysikk
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


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