dc.contributor.author | Rivera, A | |
dc.contributor.author | Valdes, L | |
dc.contributor.author | Jimenez, J | |
dc.contributor.author | Perez, I | |
dc.contributor.author | Lam, A | |
dc.contributor.author | Altshuler, E | |
dc.contributor.author | De Menorval, LC | |
dc.contributor.author | Fossum, Jon Otto | |
dc.contributor.author | Hansen, Elisabeth Lindbo | |
dc.contributor.author | Rozynek, Zbigniew Jerzy | |
dc.date.accessioned | 2017-11-02T08:15:26Z | |
dc.date.available | 2017-11-02T08:15:26Z | |
dc.date.created | 2016-09-30T15:53:29Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Applied Clay Science. 2016, 124-125 150-156. | nb_NO |
dc.identifier.issn | 0169-1317 | |
dc.identifier.uri | http://hdl.handle.net/11250/2463595 | |
dc.description.abstract | Clays have shown to be good candidates as drug delivery carriers. In the present paper, the temperature-dependent swelling of smectites was exploited to obtain composites able to release a drug in a controlled way. More specifically, synthetic fluorohectorite-ciprofloxacin composites were prepared, in which the drug molecules were intercalated between the clay layers. The drug-release systems were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermal gravimetric analysis (TGA), ultraviolet spectroscopy (UV) and atomic absorption spectrometry (AAS). The results from the X-ray diffraction allowed confirming the ciprofloxacin incorporation into the interlayer space, and the results from UV spectroscopy indicated that more than 90% of the initial drug was uptaken by the clay. The thermally activated drug release from a colloidal dispersion of nanosized composite particles in both pure water and synthetic gastric juice was evaluated at temperatures from 37 °C (body temperature) to 85 °C. The studies indicated that the clay promotes the slow release of ciprofloxacin, and that the release of drug increases with both time and temperature. The profiles of drug-release from the clay fulfilled the pharmaceutical standards for these systems. As a result, a clay-based Temperature-Controlled Release System (TCRS) with potential biomedical applications has been obtained. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.title | Smectite as ciprofloxacin delivery system: Intercalation and temperature-controlled release properties | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | submittedVersion | nb_NO |
dc.source.pagenumber | 150-156 | nb_NO |
dc.source.volume | 124-125 | nb_NO |
dc.source.journal | Applied Clay Science | nb_NO |
dc.identifier.doi | 10.1016/j.clay.2016.02.006 | |
dc.identifier.cristin | 1388394 | |
dc.relation.project | Norges forskningsråd: 228551 | nb_NO |
dc.description.localcode | This is the authors' manuscript to the article (preprint). | nb_NO |
cristin.unitcode | 194,66,20,0 | |
cristin.unitname | Institutt for fysikk | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.qualitycode | 1 | |