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dc.contributor.authorKropatsch, Regina
dc.contributor.authorMelis, Claudia
dc.contributor.authorStronen, Astrid V.
dc.contributor.authorJensen, Henrik
dc.contributor.authorEppelen, Joerg T.
dc.date.accessioned2017-10-30T13:08:52Z
dc.date.available2017-10-30T13:08:52Z
dc.date.created2015-05-26T13:38:07Z
dc.date.issued2015
dc.identifier.citationJournal of Heredity. 2015, 106 (4), 403-406.nb_NO
dc.identifier.issn0022-1503
dc.identifier.urihttp://hdl.handle.net/11250/2462901
dc.description.abstractThe Norwegian Lundehund breed of dog has undergone a severe loss of genetic diversity as a result of inbreeding and epizootics of canine distemper. As a consequence, the breed is extremely homogeneous and accurate sex identification is not always possible by standard screening of X-chromosomal loci. To improve our genetic understanding of the breed we genotyped 17 individuals using a genome-wide array of 170 000 single nucleotide polymorphisms (SNPs). Standard analyses based on expected homozygosity of X-chromosomal loci failed in assigning individuals to the correct sex, as determined initially by physical examination and confirmed with the Y-chromosomal marker, amelogenin. This demonstrates that identification of sex using standard SNP assays can be erroneous in highly inbred individuals.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Press (OUP)nb_NO
dc.titleMolecular Genetics of Sex Identification, Breed Ancestry and Polydactyly in the Norwegian Lundehund Breednb_NO
dc.typeJournal articlenb_NO
dc.description.versionsubmittedVersionnb_NO
dc.source.pagenumber403-406nb_NO
dc.source.volume106nb_NO
dc.source.journalJournal of Hereditynb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1093/jhered/esv031
dc.identifier.cristin1244466
dc.relation.projectNorges forskningsråd: 221956nb_NO
dc.relation.projectNorges forskningsråd: 223257nb_NO
dc.description.localcode© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of American Genetic Association. This is the authors' manuscript to the article.nb_NO
cristin.unitcode194,66,10,0
cristin.unitnameInstitutt for biologi
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


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