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dc.contributor.authorTyvold, Stig Sverre
dc.contributor.authorDahl, Torbjørn
dc.contributor.authorDragsund, Stein
dc.contributor.authorGunnes, Sigurd
dc.contributor.authorLyng, Oddveig
dc.contributor.authorDamås, Jan Kristian
dc.contributor.authorAadahl, Petter
dc.contributor.authorSolligård, Erik
dc.date.accessioned2017-10-05T11:35:01Z
dc.date.available2017-10-05T11:35:01Z
dc.date.created2017-08-31T09:17:40Z
dc.date.issued2017
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/11250/2458701
dc.description.abstractAortic surgery results in ischemia–reperfusion injury that induces an inflammatory response and frequent complications. The magnitude of the inflammatory response in blood and bronchi may be associated with the risk of immediate complications. The purpose of the study was to evaluate bronchial microdialysis as a continuous monitoring of cytokines in bronchial epithelial lining fluid (ELF) and to determine whether bronchial ELF cytokine levels reflect the ischemia–reperfusion injury and risk for complications during open abdominal aortic aneurysm (AAA) repair. We measured cytokines in venous blood using microdialysis and in serum for comparison. Sixteen patients scheduled for elective open AAA repair were included in a prospective observational study. Microdialysis catheters were introduced into a bronchi and a cubital vein. Eighteen cytokines were measured using a Bio‐Plex Magnetic Human Cytokine Panel. Samples were collected before and during cross‐clamping of the aorta as well as from 0 to 60 min and from 60 to 120 min of reperfusion. The ELF levels of several cytokines changed significantly during reperfusion. In particular, IL‐6 increased more than 10‐fold and IL‐13 more than 5‐fold during ischemia and reperfusion. Also, the venous levels of several inflammatory and anti‐inflammatory cytokines increased and exhibited their highest concentration during reperfusion. Both bronchial and venous cytokine levels correlated with duration of the procedure, intensive care days, and preoperative kidney disease. Three patients suffered organ failure as a direct consequence of the procedure, and in these patients the bronchial ELF concentrations of 17 of 18 cytokines differed significantly from patients without such complications. Bronchial microdialysis is suited for continuous monitoring of inflammation during open AAA repair. The bronchial ELF cytokine levels may be useful in predicting immediate complications such as organ failure in patients undergoing vascular surgery.nb_NO
dc.language.isoengnb_NO
dc.publisherWiley Open Accessnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleBronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.journalPhysiological Reportsnb_NO
dc.identifier.doi10.14814/phy2.13348
dc.identifier.cristin1490115
dc.description.localcode© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,1,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameDMF fakultetsadministrasjon
cristin.unitnameInstitutt for kreftforskning og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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