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dc.contributor.authorTripathi, Sushilnb_NO
dc.contributor.authorChristie, K Rnb_NO
dc.contributor.authorBalakrishnan, Ravinnb_NO
dc.contributor.authorHuntley, Rnb_NO
dc.contributor.authorHill, D Pnb_NO
dc.contributor.authorThommesen, Livnb_NO
dc.contributor.authorBlake, J Anb_NO
dc.contributor.authorKuiper, Martinnb_NO
dc.contributor.authorLægreid, Astridnb_NO
dc.date.accessioned2014-12-19T13:13:32Z
dc.date.available2014-12-19T13:13:32Z
dc.date.created2013-11-29nb_NO
dc.date.issued2013nb_NO
dc.identifier700133nb_NO
dc.identifier.issn1758-0463nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/245409
dc.description.abstractTranscription factors control which information in a genome becomes transcribed to produce RNAs that function in the biological systems of cells and organisms. Reliable and comprehensive information about transcription factors is invaluable for large-scale network-based studies. However, existing transcription factor knowledge bases are still lacking in well-documented functional information. Here, we provide guidelines for a curation strategy, which constitutes a robust framework for using the controlled vocabularies defined by the Gene Ontology Consortium to annotate specific DNA binding transcription factors (DbTFs) based on experimental evidence reported in literature. Our standardized protocol and workflow for annotating specific DNA binding RNA polymerase II transcription factors is designed to document high-quality and decisive evidence from valid experimental methods. Within a collaborative biocuration effort involving the user community, we are now in the process of exhaustively annotating the full repertoire of human, mouse and rat proteins that qualify as DbTFs in as much as they are experimentally documented in the biomedical literature today. The completion of this task will significantly enrich Gene Ontology-based information resources for the research community.nb_NO
dc.languageengnb_NO
dc.publisherOxford University Pressnb_NO
dc.titleGene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effortnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.pagenumber1-12nb_NO
dc.source.volume2013nb_NO
dc.source.journalDatabasenb_NO
dc.identifier.doi10.1093/database/bat062nb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for kreftforskning og molekylær medisinnb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Fakultet for naturvitenskap og teknologi, Institutt for biologinb_NO


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