Show simple item record

dc.contributor.authorEllingsen, Øyvind
dc.contributor.authorHalle, Martin
dc.contributor.authorConraads, Viviane
dc.contributor.authorStøylen, Asbjørn
dc.contributor.authorDalen, Håvard
dc.contributor.authorDelagardelle, Charles
dc.contributor.authorLarsen, Alf Inge
dc.contributor.authorHole, Torstein
dc.contributor.authorMezzani, Alessandro
dc.contributor.authorVan Craenenbroeck, Emeline M.
dc.contributor.authorVidem, Vibeke
dc.contributor.authorBeckers, Paul
dc.contributor.authorChristle, Jeffrey W.
dc.contributor.authorWinzer, Ephraim
dc.contributor.authorMangner, Norman
dc.contributor.authorWoitek, Felix
dc.contributor.authorHöllriegel, Robert
dc.contributor.authorPressler, Axel
dc.contributor.authorMonk-Hansen, Tea
dc.contributor.authorSnoer, Martin
dc.contributor.authorFeiereisen, Patrick
dc.contributor.authorValborgland, Torstein
dc.contributor.authorKjekshus, John
dc.contributor.authorHambrecht, Rainer
dc.contributor.authorGielen, Stephan
dc.contributor.authorKarlsen, Trine
dc.contributor.authorPrescott, Eva
dc.contributor.authorLinke, Axel
dc.identifier.citationCirculation. 2017, 135 (9), 839-849.nb_NO
dc.description.abstractBackground: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart failure with reduced ejection fraction. The present multicenter trial compared 12 weeks of supervised interventions of HIIT, MCT, or a recommendation of regular exercise (RRE). Methods: Two hundred sixty-one patients with left ventricular ejection fraction ≤35% and New York Heart Association class II to III were randomly assigned to HIIT at 90% to 95% of maximal heart rate, MCT at 60% to 70% of maximal heart rate, or RRE. Thereafter, patients were encouraged to continue exercising on their own. Clinical assessments were performed at baseline, after the intervention, and at follow-up after 52 weeks. Primary end point was a between-group comparison of change in left ventricular end-diastolic diameter from baseline to 12 weeks. Results: Groups did not differ in age (median, 60 years), sex (19% women), ischemic pathogenesis (59%), or medication. Change in left ventricular end-diastolic diameter from baseline to 12 weeks was not different between HIIT and MCT (P=0.45); left ventricular end-diastolic diameter changes compared with RRE were −2.8 mm (−5.2 to −0.4 mm; P=0.02) in HIIT and −1.2 mm (−3.6 to 1.2 mm; P=0.34) in MCT. There was also no difference between HIIT and MCT in peak oxygen uptake (P=0.70), but both were superior to RRE. However, none of these changes was maintained at follow-up after 52 weeks. Serious adverse events were not statistically different during supervised intervention or at follow-up at 52 weeks (HIIT, 39%; MCT, 25%; RRE, 34%; P=0.16). Training records showed that 51% of patients exercised below prescribed target during supervised HIIT and 80% above target in MCT. Conclusions: HIIT was not superior to MCT in changing left ventricular remodeling or aerobic capacity, and its feasibility remains unresolved in patients with heart failure.nb_NO
dc.publisherAmerican Heart Associationnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleHigh-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fractionnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.localcode© 2017 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervisLicense, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are madenb_NO
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for laboratoriemedisin, barne- og kvinnesykdommer

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal