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dc.contributor.authorMorland, Cecilie
dc.contributor.authorAndersson, Krister
dc.contributor.authorHaugen, Øyvind Pernell
dc.contributor.authorHadzic, Alena
dc.contributor.authorKleppa, Liv
dc.contributor.authorGille, Andreas
dc.contributor.authorRinholm, Johanne Egge
dc.contributor.authorPalibrk, Vuk
dc.contributor.authorDiget, Elisabeth Holm
dc.contributor.authorKennedy, Lauritz Hagen
dc.contributor.authorStølen, Tomas
dc.contributor.authorHennestad, Eivind
dc.contributor.authorMoldestad, Olve
dc.contributor.authorCai, Yiqing
dc.contributor.authorPuchades, Maja Amedjkouh
dc.contributor.authorOffermanns, Stefan
dc.contributor.authorVervaeke, Koen Gerard Alois
dc.contributor.authorBjørås, Magnar
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorStorm-Mathisen, Jon
dc.contributor.authorBergersen, Linda Hildegard
dc.description.abstractPhysical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.nb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleExercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalNature Communicationsnb_NO
dc.description.localcode© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,users will need to obtain permission from the license holder to reproduce the material.To view a copy of this license, visit
cristin.unitnameInstitutt for kreftforskning og molekylær medisin
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk

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