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dc.contributor.authorMai, Xiao-Mei
dc.contributor.authorChen, Yue
dc.contributor.authorCamargo, Carlos Arthuro
dc.contributor.authorLanghammer, Arnulf
dc.date.accessioned2017-06-12T07:04:47Z
dc.date.available2017-06-12T07:04:47Z
dc.date.created2012-10-03T14:35:41Z
dc.date.issued2012
dc.identifier.citationAmerican Journal of Epidemiology. 2012, 175 (10), 1029-1036.nb_NO
dc.identifier.issn0002-9262
dc.identifier.urihttp://hdl.handle.net/11250/2445685
dc.description.abstractExperimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19–55 years participated in both the second and third surveys of the Nord-Trøndelag Health Study (HUNT 2 (1995–1997) and HUNT 3 (2006–2008)). Serum 25(OH)D levels measured at baseline and anthropometric measurements taken at both baseline and follow-up were available for a random sample of 2,460 subjects. Overall, 40% of the 2,460 subjects had a serum 25(OH)D level less than 50.0 nmol/L, and 37% had a level of 50.0–74.9 nmol/L. The prevalence and cumulative incidence of obesity, defined as body mass index (weight (kg)/height (m)2) ≥30, were 12% and 15%, respectively. Lower serum 25(OH)D level was associated with a higher prevalence of obesity. In the 2,165 subjects with baseline BMI less than 30, a serum 25(OH)D level less than 50.0 nmol/L was associated with a significantly increased odds ratio for incident obesity during follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.24, 2.41). When prevalent and incident obesity were classified according to waist circumference (≥88 cm for women, ≥102 cm for men), similar results were obtained. In addition to prevalent obesity, a serum 25(OH)D level less than 50.0 nmol/L was significantly associated with new-onset obesity in adults.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Pressnb_NO
dc.titleCross-Sectional and Prospective Cohort Study of Serum 25-Hydroxyvitamin D Level and Obesity in Adultsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1029-1036nb_NO
dc.source.volume175nb_NO
dc.source.journalAmerican Journal of Epidemiologynb_NO
dc.source.issue10nb_NO
dc.identifier.doi10.1093/aje/kwr456
dc.identifier.cristin948451
dc.relation.projectNorges forskningsråd: 201895nb_NO
dc.description.localcodeAmerican Journal of Epidemiology © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This is the authors' accepted and refereed manuscript to the article.nb_NO
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for samfunnsmedisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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