Institutt for bioingeniørfag: Nye registreringer
Viser treff 41-60 av 184
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A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
(Peer reviewed; Journal article, 2023)The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, ... -
NRF2 drives an oxidative stress response predictive of breast cancer
(Peer reviewed; Journal article, 2022)Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related ... -
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
(Peer reviewed; Journal article, 2021)Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance ... -
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
(Peer reviewed; Journal article, 2021)Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of ... -
Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells
(Journal article; Peer reviewed, 2022) -
Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement
(Peer reviewed; Journal article, 2021)Proliferative diabetic retinopathy (PDR) is a sight-threatening diabetic complication in urgent need of new therapies. In this study we identify potential molecular mechanisms and target candidates in the pathogenesis of ... -
Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality
(Peer reviewed; Journal article, 2021)Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive ... -
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
(Peer reviewed; Journal article, 2021)Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself ... -
Praksisstudienes omfang og organisering i bioingeniørutdanningen
(Peer reviewed; Journal article, 2022)Siden 2005 har omfang og innhold i bioingeniørutdanningen vært definert av en nasjonal rammeplan for å sikre likeverdig sluttkompetanse for alle kandidater. Fra 2019 ble en ny forskrift om nasjonale retningslinjer fastsatt. ... -
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
(Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Validering av metode for kvantifisering av antiepileptika i serum ved bruk av ny detektor (Xevo TQ-XS) på UPLC-MSMS
(Bachelor thesis, 2022)Validering av metode for kvantifisering av antiepileptika (karbamazepin, karbamazepinepoksid, likarbazepin og zonisamid) i serum ble gjennomført på MS-detektoren Xevo TQ-XS. Dette er en ny MS-versjon som skal tas i bruk ... -
Complex I and its role in aerobic and anaerobic growth of Cereibacter sphaeroides
(Bachelor thesis, 2022)Complex I is a big protein complex in the electron transport chain and works as the entry point of electrons from NADH into the electron transport chain. Complex I in Cereibacter sphaeroides differs from complex I in many ... -
Beregning av fritt kalsium i serum; hvilken betydning har valg av albuminmetode?
(Bachelor thesis, 2022)Konsentrasjonen av fritt kalsium i fullblod og i plasma bestemmes ved bruk av Ca2+-ion-selektive elektroder. Dette er en manuell og ressurskrevende analyse. Flere laboratorier har utarbeidet indirekte metoder for å beregne ... -
Etablering av real-time PCR-metoder for påvisning og differensiering av Mycobacterium abscessus complex subspecies ved bruk av molekylære beacon-prober
(Bachelor thesis, 2022)Mycobacterium abscessus complex er et bakteriekompleks som omfatter tre subspecies; Mycobacterium abscessus subsp. abscessus, Mycobacterium abscessus subsp. massiliense og Mycobacterium abscessus subsp. bolletii. Dette ... -
Determining the impact of the R249S mutation on Tp53 gene on cell survivability during AFB1 exposure
(Bachelor thesis, 2022)Hepatocellular Carcinoma (HCC) is one of the most frequent and malignant cancers worldwide and is found to be endemic in the same geographically areas as high exposure with Aflatoxin B1 (AFB1). AFB1 is a mycotoxin, naturally ... -
Maturation of plastid cytochrome c: A contribution to the study of the function of CCS4 and CCDA in Chlamydomonas reinhardtii
(Bachelor thesis, 2022)Cytochromes c are electron carrier proteins with a heme group covalently attached to a CXXCH motif. In the plastid, cytochromes c are involved in photosynthesis and their assembly requires the attachment of heme to the ... -
Characterization of Mam301 in Fission yeast
(Bachelor thesis, 2022)Background: Magnesium is an essential ion that is a cofactor for many important proteins and enzymes in the body. It also functions as a counterion for negative ions and thus helps stabilize many important molecules. ... -
Metodeutprøving av «klar til bruk» fargereagenser til HE-farging av vevsprøver til kreftdiagnostikk.
(Bachelor thesis, 2022)Dette prosjektet gjennomføres som den avsluttende bacheloroppgaven for bioingeniørutdanningen ved institutt for bioingeniørfag på det naturfaglige fakultet på Norges teknisk-naturvitenskaplige universitet (NTNU). I en ... -
Utvikling av metode for deteksjon av karbohydrater i urin med HPAE-PAD
(Bachelor thesis, 2022)Bakgrunn: Multippel sklerose (MS) er en kronisk autoimmun sykdom hvor myelinet og aksonene i sentralnervesystemet blir angrepet av kroppens egne immunceller. Tidligere forskning tyder på at glutenproteiner kan øke tarmens ... -
Kvalitetsrevisjon ved Avdeling for patologi, St. Olavs hospital
(Bachelor thesis, 2022)Hensikten med oppgaven var å undersøke om kvalitetsrevisjon var en god måte å avdekke hvorvidt Seksjon for spesialanalyser ved Avdeling for patologi på St. Olavs Hospital følger NS-EN ISO 15189:2012 Medisinske laboratorier ...