• FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells 

      Quist-Løkken, Ingrid; Andersson-Rusch, Clara Leticia; Kastnes, Martin Haugrud; Jürgen Markus Kolos, , Jürgen Markus; Jatzlau, Jerome; Hella, Hanne; Olsen, Oddrun Elise; Sundan, Anders; Knaus, Petra; Hausch, Felix; Holien, Toril (Journal article; Peer reviewed, 2023)
      Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ...
    • GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients 

      Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril (Journal article; Peer reviewed, 2019)
      Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ...
    • Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer 

      Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Peer reviewed; Journal article, 2023)
      Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved ...