Blar i Institutt for bioingeniørfag på tittel

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    • Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling 

      Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ...

    • CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity 

      Filppu, Paulinna; Ramanathan, Jayendrakishore; Granberg, Kirsi J.; Gucciardo, Erika; Haapasalo, Hannu; Lehti, Kaisa; Nykter, Matti; Le Joncour, Vadim; Laakkonen, Pirjo (Peer reviewed; Journal article, 2021)
      Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance ...

    • Cd11c‐cd8 spatial cross presentation: A novel approach to link immune surveillance and patient survival in soft tissue sarcoma 

      Su, Yanhong; Tsagozis, Panagiotis; Papakonstantinou, Andri; Tobin, Nicholas P.; Gultekin, Okan; Malmerfelt, Anna; Ingelshed, Katrine; Neo, Shi Yong; Lundquist, Johanna; Chaabane, Wiem; Nisancioglu, Maya H.; Leiss, Lina; Östman, Arne; Bergh, Jonas; Sedimbi, Saikiran K.; Lehti, Kaisa; Lehti, Kaisa; Lundqvist, Andreas; Stragliotto, Christina L.; Haglund, Felix; Ehnman, Monika (Peer reviewed; Journal article, 2021)
      Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part sarcoma, and angiosarcoma even though formal indication is lacking. ...

    • Cellulært uttrykk av miR-143 og miR-145, påvist ved in-situ hybridisering i parafininnstøpt vev. 

      Bakkemyr Helene (Bachelor thesis, 2020)
      Hensikten med prosjektet var å utføre in situ hybridisering for å undersøke lokalisasjonen til spesifikke mikroRNA-molekyler i vevsområder med celleforandringer og betennelsesreaksjon. Dette ble utført for vevsområder med ...

    • Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles 

      Heck, Kathleen; Lindholm, Håvard Takle; Niederdorfer, Barbara; Tsirvouli, Eirini; Kuiper, Martin; Flobak, Åsmund; Lægreid, Astrid Renner; Thommesen, Liv (Journal article; Peer reviewed, 2023)

    • Characterization of Mam301 in Fission yeast 

      Eidsmo, Nina Winje (Bachelor thesis, 2022)
      Background: Magnesium is an essential ion that is a cofactor for many important proteins and enzymes in the body. It also functions as a counterion for negative ions and thus helps stabilize many important molecules. ...

    • Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance 

      Pietilä, Elina A.; Gonzalez-Molina, Jordi.; Moyano-Galceran, Lidia; Jamalzadeh, Sanaz; Zhang, Kaiyang; Lehtinen, Laura; Turunen, S Pauliina; Martins, Tomás A; Gultekin, Okan; Lamminen, Tarja; Kaipio, Katja; Joneborg, Ulrika; Hynninen, Johanna; Hietanen, Sakara; Grénman, Seija; Lehtonen, Rainer; Hautaniemi, Sampsa; Carpén, Olli; Carlson, Joseph W.; Lehti, Kaisa (Peer reviewed; Journal article, 2021)
      Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself ...

    • Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen 

      Kuiper, Martin; Lægreid, Astrid; Flobak, Åsmund; Thommesen, Liv; Team, Dream (Journal article; Peer reviewed, 2019)
      The effectiveness of most cancer targeted therapies is short-lived. Tumors often developresistance that might be overcome with drug combinations. However, the number of possiblecombinations is vast, necessitating data-driven ...

    • Complex I and its role in aerobic and anaerobic growth of Cereibacter sphaeroides 

      Fondevik, Eline (Bachelor thesis, 2022)
      Complex I is a big protein complex in the electron transport chain and works as the entry point of electrons from NADH into the electron transport chain. Complex I in Cereibacter sphaeroides differs from complex I in many ...

    • Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer 

      Miki, Yuichiro; Yashiro, Masakazu; Moyano-Galceran, Lidia; Sugimoto, Atsushi; Ohira, Masaichi; Lehti, Kaisa (Peer reviewed; Journal article, 2020)
      Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although the treatment outcome of GC has improved, the survival of patients with GC at stages III and IV remains unsatisfactory. Among several ...

    • Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes 

      Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)
      Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ...

    • Deteksjonsgrenser for kvalitative urinanalyser 

      Aasvold, Anna Kristine; Sund, Julie Kaland (Bachelor thesis, 2020)
      Analyse av urin ved bruk av urinstrimmel gir semi-kvantitative prøveresultater, og er gradert i nivåene 1+, 2+, 3+ og 4+. Prøveresultatene tolkes likevel ofte til å være enten positive eller negative ut fra deteksjonsgrensen. ...

    • Deteksjonsgrenser for kvalitative urinanalyser 

      Wiktil, Therese Nerland; Wormdahl, Sofie Breisnes (Bachelor thesis, 2021)
      Oppgaven er gitt av Avdeling for medisinsk biokjemi ved St.Olavs Hospital. Formålet med oppgaven er å undersøke responskurvene for testfeltene protein (albumin), glukose og blod (erytrocytter) på urinstrimmelen Combur ...

    • Determining the impact of the R249S mutation on Tp53 gene on cell survivability during AFB1 exposure 

      Fonnes, Helene (Bachelor thesis, 2022)
      Hepatocellular Carcinoma (HCC) is one of the most frequent and malignant cancers worldwide and is found to be endemic in the same geographically areas as high exposure with Aflatoxin B1 (AFB1). AFB1 is a mycotoxin, naturally ...

    • DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy 

      Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016)
      Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well ...

    • Digital image analysis of clinical biomarker candidates in ovarian cancer 

      Kvalsvik, Tomine; Almenningen, Anna Moe (Bachelor thesis, 2021)
      FGFR4 og MMP14 uttrykt i same tumor er kjend for å leie til aggressive tumorar. Frå eit pågåande forskingsprosjekt frå Lehti gruppa syner resultat at høgt uttrykt FGFR4 er relatert til overuttrykt MMP14 i tumor. I vår ...

    • Digital Imaging of Ovarian Cancer Biomarkers 

      Flaten, Tale Boym; Jenseg-Wang, Martine (Bachelor thesis, 2023)
      Researchers study both cancer and tumor microenvironment (TME) in carcinomas in order to uncover correlations between the tumor biology and the diagnostic profiles of the patients affected. The survival perspectives for ...

    • Digital kvalitetsrevisjon ved Avdeling for patologi, St. Olavs Hospital 

      Tyldum, Anne Marte; Åmland, Ingrid (Bachelor thesis, 2020)
      Bakgrunnen for oppgaven var et behov for å gjennomføre en intern kvalitetsrevisjon på Avdeling for patologi, Seksjon for biopsi og obduksjon innenfor fagområdene preparering og HE-farging. Hensikten med revisjonen var å ...

    • Digital læringsressurs i medisinsk mikrobiologi 

      Trondal, Sebastian Skårslette; Stillingen, Simen; Banko, Hozan (Bachelor thesis, 2023)
      Hensikten med denne oppgaven er å skape nytt innhold til den allerede eksisterende digitale opplæringsressursen som er tilgjengelig for studenter ved bioingeniørutdanningen. I denne oppgaven er det hovedfokus på urin som ...

    • Digital læringsressurs i nukleærmedisin 

      Deurs, Susanne Hilmen van; Syversen, Vår K.; Skotner, Kaja (Bachelor thesis, 2023)
      Nukleærmedisin var en del av emnet HBIOT2021 Medisinsk Laboratorieteknologi – Kvantitative teknikker, og evaluering av studenter tydet på at temaet var utfordrende. Da det kun ble gitt åtte timer med forelesning om temaet, ...