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dc.contributor.authorElvemo, Nicolas-Andreas L.
dc.contributor.authorNilsen, Kristian Bernhard
dc.contributor.authorLandrø, Nils Inge
dc.contributor.authorBorchgrevink, Petter Chr.
dc.contributor.authorHåberg, Asta
dc.identifier.citationJournal of Pain Research 2014, 7:425-437nb_NO
dc.description.abstractPatients with chronic pain have impaired cognitive functions, including decision making, as shown with the Iowa gambling task (IGT). The main aim of this study was to elucidate whether patients' decision making is associated with a lack of the anticipatory skin conductance response (SCR). An increase in anticipatory SCR before making unfavorable choices is known to guide decisions in healthy controls during the IGT. Since several brain regions involved in decision making are reported to have altered morphology in patients with chronic pain, the second aim was to explore the associations between IGT performance and brain structure volumes. Eighteen patients with chronic pain of mixed etiology and 19 healthy controls matched in terms of age, sex, and education were investigated with a computerized IGT during the recording of SCR, heart rate, and blood pressure. The participants also underwent neuropsychological testing, and three-dimensional T1-weighted cerebral magnetic resonance images were obtained. Contrary to controls, patients did not generate anticipatory SCRs before making unfavorable choices, and they switched between decks of cards during the late phase of the IGT significantly more often, and this was still observed after adjusting for depression scores. None of the other autonomic measures differed during IGT performance in either group or between groups. In patients, IGT scores correlated positively with total cortical grey matter volume. In controls, there was no such association, but their IGT scores correlated with the anticipatory SCR. It may be speculated that the reduction in anticipatory SCRs makes the chronic pain patients rely more on cortical resources during decision making.nb_NO
dc.publisherDove Medical Pressnb_NO
dc.titlePatients With chronic pain lack somatic markers during decision-makingnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.subject.nsiIowa gambling task, skin conductance response, autonomic measures, magnetic resonance imaging, cortexnb_NO
dc.source.journalJournal of Pain Researchnb_NO
dc.description.localcodeThis work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.nb_NO

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