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dc.contributor.authorBathen, Tone Frost
dc.contributor.authorGeurts, Brigitte
dc.contributor.authorSitter, Beathe
dc.contributor.authorFjøsne, Hans Erikssønn
dc.contributor.authorLundgren, Steinar
dc.contributor.authorBuydens, Lutgarde M. C.
dc.contributor.authorGribbestad, Ingrid S
dc.contributor.authorPostma, Geert
dc.contributor.authorGiskeødegård, Guro F.
dc.date.accessioned2015-11-24T08:16:14Z
dc.date.accessioned2015-12-09T14:38:13Z
dc.date.available2015-11-24T08:16:14Z
dc.date.available2015-12-09T14:38:13Z
dc.date.issued2013
dc.identifier.citationPLoS ONE 2013, 8(4)nb_NO
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/2367378
dc.description.abstractIn this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. With the current methods, delineation of the tumor borders during breast cancer surgery is a challenging task for the surgeon, and a significant number of re-surgeries occur. We analyzed 328 tissue samples from 228 breast cancer patients using HR MAS MRS. Partial least squares discriminant analysis (PLS-DA) was applied to discriminate between tumor and non-involved adjacent tissue. Using proper double cross validation, high sensitivity and specificity of 91% and 93%, respectively was achieved. Analysis of the loading profiles from both principal component analysis (PCA) and PLS-DA showed the choline-containing metabolites as main biomarkers for tumor content, with phosphocholine being especially high in tumor tissue. Other indicative metabolites include glycine, taurine and glucose. We conclude that metabolic profiling by HR MAS MRS may be a potential method for on-line analysis of resection margins during breast cancer surgery to reduce the number of re-surgeries and risk of local recurrence.nb_NO
dc.language.isoengnb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.titleFeasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgerynb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-11-24T08:16:14Z
dc.source.volume8nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1371/journal.pone.0061578
dc.identifier.cristin1040198
dc.description.localcode© 2013 Bathen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO


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