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dc.contributor.authorKarlsen, Morten
dc.contributor.authorLiu, Huiling
dc.contributor.authorJohansen, Jon Eigill
dc.contributor.authorHoff, Bård Helge
dc.date.accessioned2015-09-30T12:31:58Z
dc.date.accessioned2015-11-06T11:41:08Z
dc.date.available2015-09-30T12:31:58Z
dc.date.available2015-11-06T11:41:08Z
dc.date.issued2014
dc.identifier.citationMolecules 2014, 19(9):13526-13540nb_NO
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11250/2359571
dc.description.abstract(−)-Δ9-Tetrahydrocannabinol is the principal psychoactive component of the cannabis plant and also the active ingredient in some prescribed drugs. To detect and control misuse and monitor administration in clinical settings, reference samples of the native drugs and their metabolites are needed. The accuracy of liquid chromatography/mass spectrometric quantification of drugs in biological samples depends among others on ion suppressing/alteration effects. Especially, 13C-labeled drug analogues are useful for minimzing such interferences. Thus, to provide internal standards for more accurate quantification and for identification purpose, synthesis of [13C4]-Δ9-tetrahydrocannabinol and [13C4]-11-nor-9-carboxy-Δ9-tetrahydrocannabinol was developed via [13C4]-olivetol. Starting from [13C4]-olivetol the synthesis of [13C4]-11-nor-9-carboxy-Δ9- tetrahydrocannabinol was shortened from three to two steps by employing nitromethane as a co-solvent in condensation with (+)-apoverbenone.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.titleSynthesis of [13C4]-labeled ∆9-tetrahydrocannabinol and 11-nor-9-carboxy-∆9-tetrahydrocannabinol as internal standards for reducing ion supressing/alteration effects in LC/MS-MS quantificationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-09-30T12:31:57Z
dc.source.volume19nb_NO
dc.source.journalMoleculesnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.3390/molecules190913526
dc.identifier.cristin1188517
dc.description.localcodeThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO


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