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dc.contributor.authorWinje, Brita Askeland
dc.contributor.authorOftung, Fredrik
dc.contributor.authorKorsvold, Gro Ellen
dc.contributor.authorMannsåker, Turid
dc.contributor.authorJeppesen, Anette Skistad
dc.contributor.authorHarstad, Ingunn
dc.contributor.authorHeier, Berit Tafjord
dc.contributor.authorHeldal, Einar
dc.date.accessioned2015-09-30T07:27:05Z
dc.date.accessioned2015-10-28T11:50:22Z
dc.date.available2015-09-30T07:27:05Z
dc.date.available2015-10-28T11:50:22Z
dc.date.issued2008
dc.identifier.citationBMC Infectious Diseases 2008, 8nb_NO
dc.identifier.issn1471-2334
dc.identifier.urihttp://hdl.handle.net/11250/2358304
dc.description.abstractBackground: QuantiFERON®TB Gold (QFT) is a promising blood test for tuberculosis infection but with few data so far from immigrant screening. The aim of this study was to compare results of QFT and tuberculin skin test (TST) among newly arrived asylum seekers in Norway and to assess the role of QFT in routine diagnostic screening for latent tuberculosis infection. Methods: The 1000 asylum seekers (age ≥ 18 years) enrolled in the study were voluntarily recruited from 2813 consecutive asylum seekers arriving at the national reception centre from September 2005 to June 2006. Participation included a QFT test and a questionnaire in addition to the mandatory TST and chest X-ray. Results: Among 912 asylum seekers with valid test results, 29% (264) had a positive QFT test whereas 50% (460) tested positive with TST (indurations ≥ 6 mm), indicating a high proportion of latent infection within this group. Among the TST positive participants 50% were QFT negative, whereas 7% of the TST negative participants were QFT positive. There was a significant association between increase in size of TST result and the likelihood of being QFT positive. Agreement between the tests was 71–79% depending on the chosen TST cut-off and it was higher for nonvaccinated individuals. Conclusion: By using QFT in routine screening, further follow-up could be avoided in 43% of the asylum seekers who would have been referred if based only on a positive TST (≥ 6 mm). The proportion of individuals referred will be the same whether QFT replaces TST or is used as a supplement to confirm a positive TST, but the number tested will vary greatly. All three screening approaches would identify the same proportion (88–89%) of asylum seekers with a positive QFT and/or a TST ≥ 15 mm, but different groups will be missed.nb_NO
dc.language.isoengnb_NO
dc.publisherBioMed Centralnb_NO
dc.titleScreening for tuberculosis infection among newly arrived asylum seekers: Comparison of QuantiFERON®TB Gold with tuberculin skin testnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-09-30T07:27:05Z
dc.source.volume8nb_NO
dc.source.journalBMC Infectious Diseasesnb_NO
dc.identifier.doi10.1186/1471-2334-8-65
dc.identifier.cristin336735
dc.description.localcode© 2008 Winje et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO


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